1jvb
From Proteopedia
(New page: 200px<br /> <applet load="1jvb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jvb, resolution 1.85Å" /> '''ALCOHOL DEHYDROGENA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1JVB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JVB OCA]]. | + | 1JVB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1]]. Structure known Active Sites: ZNC and ZNS. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JVB OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of the alcohol dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus at 1.85 A resolution., Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A, J Mol Biol. 2002 Apr 26;318(2):463-77. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12051852 12051852] | Crystal structure of the alcohol dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus at 1.85 A resolution., Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A, J Mol Biol. 2002 Apr 26;318(2):463-77. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12051852 12051852] | ||
| + | [[Category: Alcohol dehydrogenase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Sulfolobus solfataricus]] | [[Category: Sulfolobus solfataricus]] | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:56:06 2007'' |
Revision as of 09:51, 30 October 2007
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ALCOHOL DEHYDROGENASE FROM THE ARCHAEON SULFOLOBUS SOLFATARICUS
Overview
The crystal structure of a medium-chain NAD(H)-dependent alcohol, dehydrogenase (ADH) from an archaeon has been solved by multiwavelength, anomalous diffraction, using a selenomethionine-substituted enzyme. The, protein (SsADH), extracted from the hyperthermophilic organism Sulfolobus, solfataricus, is a homo-tetramer with a crystallographic 222 symmetry., Despite the low level of sequence identity, the overall fold of the, monomer is similar to that of the other homologous ADHs of known, structure. However, a significant difference is the orientation of the, catalytic domain relative to the coenzyme-binding domain that results in a, larger interdomain cleft. At the bottom of this cleft, the catalytic zinc, ion is coordinated tetrahedrally and lacks the zinc-bound water molecule, that is ... [(full description)]
About this Structure
1JVB is a [Single protein] structure of sequence from [Sulfolobus solfataricus] with ZN as [ligand]. Active as [Alcohol dehydrogenase], with EC number [1.1.1.1]. Structure known Active Sites: ZNC and ZNS. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the alcohol dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus at 1.85 A resolution., Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A, J Mol Biol. 2002 Apr 26;318(2):463-77. PMID:12051852
Page seeded by OCA on Tue Oct 30 11:56:06 2007
