3l6c

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[[Image:3l6c.png|left|200px]]
 
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{{STRUCTURE_3l6c| PDB=3l6c | SCENE= }}
{{STRUCTURE_3l6c| PDB=3l6c | SCENE= }}
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===X-ray crystal structure of rat serine racemase in complex with malonate a potent inhibitor===
===X-ray crystal structure of rat serine racemase in complex with malonate a potent inhibitor===
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{{ABSTRACT_PUBMED_20106978}}
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==Function==
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[[http://www.uniprot.org/uniprot/SRR_RAT SRR_RAT]] Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:16713567</ref> <ref>PMID:20106978</ref>
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{{ABSTRACT_PUBMED_20106978}}
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==About this Structure==
==About this Structure==
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3L6C is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L6C OCA].
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[[3l6c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L6C OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20106978</ref><references group="xtra"/>
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<ref group="xtra">PMID:020106978</ref><references group="xtra"/><references/>
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Serine racemase]]
[[Category: Serine racemase]]
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[[Category: Pyridoxal phosphate]]
[[Category: Pyridoxal phosphate]]
[[Category: Serine racemase]]
[[Category: Serine racemase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:38:16 2010''
 

Revision as of 20:50, 4 April 2013

Template:STRUCTURE 3l6c

Contents

X-ray crystal structure of rat serine racemase in complex with malonate a potent inhibitor

Template:ABSTRACT PUBMED 20106978

Function

[SRR_RAT] Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.[1] [2]

About this Structure

3l6c is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Smith MA, Mack V, Ebneth A, Moraes I, Felicetti B, Wood M, Schonfeld D, Mather O, Cesura A, Barker J. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J Biol Chem. 2010 Apr 23;285(17):12873-81. Epub 2010 Jan 27. PMID:20106978 doi:10.1074/jbc.M109.050062
  1. ↑ Panatier A, Theodosis DT, Mothet JP, Touquet B, Pollegioni L, Poulain DA, Oliet SH. Glia-derived D-serine controls NMDA receptor activity and synaptic memory. Cell. 2006 May 19;125(4):775-84. PMID:16713567 doi:10.1016/j.cell.2006.02.051
  2. ↑ Smith MA, Mack V, Ebneth A, Moraes I, Felicetti B, Wood M, Schonfeld D, Mather O, Cesura A, Barker J. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J Biol Chem. 2010 Apr 23;285(17):12873-81. Epub 2010 Jan 27. PMID:20106978 doi:10.1074/jbc.M109.050062

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