1eem

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[[Image:1eem.gif|left|200px]]<br /><applet load="1eem" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1eem.gif|left|200px]]
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caption="1eem, resolution 2.00&Aring;" />
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'''GLUTATHIONE TRANSFERASE FROM HOMO SAPIENS'''<br />
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{{Structure
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|PDB= 1eem |SIZE=350|CAPTION= <scene name='initialview01'>1eem</scene>, resolution 2.00&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''GLUTATHIONE TRANSFERASE FROM HOMO SAPIENS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1EEM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=GSH:'>GSH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EEM OCA].
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1EEM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EEM OCA].
==Reference==
==Reference==
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Identification, characterization, and crystal structure of the Omega class glutathione transferases., Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk BA, Perregaux DE, Gabel CA, Geoghegan KF, Pandit J, J Biol Chem. 2000 Aug 11;275(32):24798-806. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10783391 10783391]
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Identification, characterization, and crystal structure of the Omega class glutathione transferases., Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk BA, Perregaux DE, Gabel CA, Geoghegan KF, Pandit J, J Biol Chem. 2000 Aug 11;275(32):24798-806. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10783391 10783391]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: putative oxidoreductase]]
[[Category: putative oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:26:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:54:34 2008''

Revision as of 08:54, 20 March 2008

Image:1eem.gif


PDB ID 1eem

Drag the structure with the mouse to rotate
, resolution 2.00Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



GLUTATHIONE TRANSFERASE FROM HOMO SAPIENS


Overview

A new class of glutathione transferases has been discovered by analysis of the expressed sequence tag data base and sequence alignment. Glutathione S-transferases (GSTs) of the new class, named Omega, exist in several mammalian species and Caenorhabditis elegans. In humans, GSTO 1-1 is expressed in most tissues and exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities characteristic of the glutaredoxins. The structure of GSTO 1-1 has been determined at 2.0-A resolution and has a characteristic GST fold (Protein Data Bank entry code ). The Omega class GSTs exhibit an unusual N-terminal extension that abuts the C terminus to form a novel structural unit. Unlike other mammalian GSTs, GSTO 1-1 appears to have an active site cysteine that can form a disulfide bond with glutathione.

About this Structure

1EEM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Identification, characterization, and crystal structure of the Omega class glutathione transferases., Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk BA, Perregaux DE, Gabel CA, Geoghegan KF, Pandit J, J Biol Chem. 2000 Aug 11;275(32):24798-806. PMID:10783391

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