3two

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[[Image:3two.png|left|200px]]
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==The crystal structure of CAD from Helicobacter pylori complexed with NADP(H)==
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<StructureSection load='3two' size='340' side='right' caption='[[3two]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3two]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TWO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cad ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cinnamyl-alcohol_dehydrogenase Cinnamyl-alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.195 1.1.1.195] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3two FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3two OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3two RCSB], [http://www.ebi.ac.uk/pdbsum/3two PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cinnamyl alcohol dehydrogenase is a zinc- and NADPH-dependent dehydrogenase catalyzing the reversible conversion of p-hydroxycinnamaldehydes to their corresponding hydroxycinnamyl alcohols. A CAD homolog from Helicobacter pylori (HpCAD) possesses broad substrate specificities like the plant CADs and additionally a dismutation activity converting benzaldehyde to benzyl alcohol and benzoic acid. We have determined the crystal structure of HpCAD complexed with NADP(H) at 2.18A resolution to get a better understanding of this class of CAD outside of plants. The structure of HpCAD is highly homologous to the sinapyl alcohol dehydrogenase and the plant CAD with well-conserved residues involved in catalysis and zinc binding. However, the NADP(H) binding mode of the HpCAD has been found to be significantly different from those of plant CADs.
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{{STRUCTURE_3two| PDB=3two | SCENE= }}
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Unusual NADPH conformation in the crystal structure of a cinnamyl alcohol dehydrogenase from Helicobacter pylori in complex with NADP(H) and substrate docking analysis.,Seo KH, Zhuang N, Chen C, Song JY, Kang HL, Rhee KH, Lee KH FEBS Lett. 2012 Feb 17;586(4):337-43. Epub 2012 Jan 21. PMID:22269576<ref>PMID:22269576</ref>
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===The crystal structure of CAD from Helicobacter pylori complexed with NADP(H)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_22269576}}
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==About this Structure==
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[[3two]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWO OCA].
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==See Also==
==See Also==
*[[Alcohol dehydrogenase|Alcohol dehydrogenase]]
*[[Alcohol dehydrogenase|Alcohol dehydrogenase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022269576</ref><references group="xtra"/>
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__TOC__
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[[Category: Cinnamyl-alcohol dehydrogenase]]
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</StructureSection>
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[[Category: Helicobacter pylori]]
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[[Category: Cong, C.]]
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[[Category: Lee, K H.]]
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[[Category: Seo, K H.]]
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[[Category: Zhuang, N N.]]
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[[Category: Cinnamyl-alcohol dehydrogenase]]
[[Category: Cinnamyl-alcohol dehydrogenase]]
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Cong, C]]
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[[Category: Lee, K H]]
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[[Category: Seo, K H]]
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[[Category: Zhuang, N N]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]

Revision as of 16:30, 9 December 2014

The crystal structure of CAD from Helicobacter pylori complexed with NADP(H)

3two, resolution 2.18Å

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