DAHP synthase
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 2: | Line 2: | ||
== Function == | == Function == | ||
| - | '''DAHP synthase''' or '''3-deoxy-D-arabino-heptulosonate 7-phosphate synthase''' (DAHPS) catalyzes the conversion of phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate to 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) and phosphate. DAHPS is part of the shikimate pathway. DAHPS requires a bivalent metal ion cofactor for normal activity. <scene name='70/708806/Cv/6'>DAHPS is a tetramer</scene>. DAHPS exhibits feedback inhibition by aromatic amino acids like tyrosine, phenylalanine and tryptophan.<ref>PMID:1682314</ref> | + | '''DAHP synthase''' or '''3-deoxy-D-arabino-heptulosonate 7-phosphate synthase''' or '''phospho-2-dehydro-3-deoxyheptonate aldolase''' (DAHPS) catalyzes the conversion of phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate to 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) and phosphate. DAHPS is part of the shikimate pathway. DAHPS requires a bivalent metal ion cofactor for normal activity. <scene name='70/708806/Cv/6'>DAHPS is a tetramer</scene>. DAHPS exhibits feedback inhibition by aromatic amino acids like tyrosine, phenylalanine and tryptophan.<ref>PMID:1682314</ref> |
== Structural highlights == | == Structural highlights == | ||
| Line 13: | Line 13: | ||
</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of DAHP synthase == | ||
| - | |||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *DAHP synthase | ||
| - | |||
| - | **[[1vr6]] - TmDAHPS – ''Thermotoga maritima''<br /> | ||
| - | **[[3pg8]] - TmDAHPS catalytic domain<br /> | ||
| - | **[[1ofp]] - yDAHPS – yeast<br /> | ||
| - | **[[1ofb]], [[1ofq]] - yDAHPS + Mn<br /> | ||
| - | **[[4uma]], [[4umb]], [[4umc]] - NmDAHPS + Mn – ''Nisseria meningitidis''<br /> | ||
| - | **[[4ixx]] - NmDAHPS (mutant) + Mn <br /> | ||
| - | **[[3tqk]] - DAHPS + Mn – ''Francisella tularensis''<br /> | ||
| - | **[[3nvt]] - LmDAHPS + Mn – ''Listeria monocytogenes''<br /> | ||
| - | |||
| - | *DAHP synthase binary complex | ||
| - | |||
| - | **[[4hsn]] - NmDAHPS + Mn + PEP <br /> | ||
| - | **[[5cz0]], [[5d02]], [[5d03]], [[5d09]], [[4ucg]] - NmDAHPS (mutant) + Mn + PEP <br /> | ||
| - | **[[5czt]], [[5d04]] - NmDAHPS (mutant) + Mn + phenylalanine <br /> | ||
| - | **[[5dcd]] - MnDAHPS + Mn + tyrosine <br /> | ||
| - | **[[5dce]] - MnDAHPS + Mn + tryptophan <br /> | ||
| - | **[[4uc5]] - MnDAHPS + Mn + phenylalanine <br /> | ||
| - | **[[4c1k]] - PfDAHPS + Cd + PEP – ''Pyrococcus furiosus''<br /> | ||
| - | **[[1zco]] - PfDAHPS + Mn + PEP <br /> | ||
| - | **[[1of6]] - yDAHPS + Mn + tyrosine <br /> | ||
| - | **[[1hfb]] - yDAHPS + PEP <br /> | ||
| - | **[[1oab]] - yDAHPS + Mn + PEP <br /> | ||
| - | **[[1ofa]] - yDAHPS + Co + PEP <br /> | ||
| - | **[[1ofr]] - yDAHPS + Mn + phenylalanine<br /> | ||
| - | **[[1og0]] - yDAHPS (mutant) + Mn + phenylalanine <br /> | ||
| - | **[[2b7o]] - MtDAHPS + Mn + PEP – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[3nud]] - MtDAHPS + phenylalanine<br /> | ||
| - | **[[2ypo]], [[5e2l]] - MtDAHPS + Mn + phenylalanine<br /> | ||
| - | **[[3nue]], [[5e5g]], [[5ex4]] - MtDAHPS + Mn + tryptophan<br /> | ||
| - | **[[2ypp]], [[5e40]], [[5e4n]] - MtDAHPS + Mn + tyrosine<br /> | ||
| - | **[[3nv8]] - MtDAHPS + Mn + PEP <br /> | ||
| - | **[[3pfp]] - MtDAHPS + Mn + inhibitor <br /> | ||
| - | **[[1qr7]] - EcDAHPS + Pb + PEP – ''Escherichia coli''<br /> | ||
| - | **[[1gg1]] - EcDAHPS + Mn + phosphoglycolate <br /> | ||
| - | **[[5cks]] - EcDAHPS + DAHP oxime<br /> | ||
| - | **[[1n8f]] – EcDAHPS (mutant) + Mn + PEP<br /> | ||
| - | **[[1ofo]] - yDAHPS + phosphoglycolate | ||
| - | **[[1vs1]] - DAHPS + Mn + PEP – ''Aeropyrum pernix''<br /> | ||
| - | **[[2w19]] - MtDAHPS + chorismate mutase <br /> | ||
| - | **[[5huc]] - CgDAHPS + Mn + PEP – ''Corynebacterium glutamicum''<br /> | ||
| - | **[[3tfc]] - LmDAHPS + Mn + PEP <br /> | ||
| - | |||
| - | *DAHP synthase higher complex | ||
| - | |||
| - | **[[1of8]] - yDAHPS + Co + PEP + glycerol-3-phosphate<br /> | ||
| - | **[[1rzm]] - TmDAHPS + Cd + PEP + erythrose-4-phosphate<br /> | ||
| - | **[[3pg9]] – TmDAHPS + tyrosine + inhibitor<br /> | ||
| - | **[[1kfl]] - EcDAHPS + Mn + PEP + phenylalanine <br /> | ||
| - | **[[4hso]] - MnDAHPS (mutant) + Mn + PEP + tyrosine <br /> | ||
| - | **[[5dcb]] - MnDAHPS + Mn + PEP + phenylalanine <br /> | ||
| - | **[[5czs]], [[5d05]] - MnDAHPS (mutant) + Mn + PEP + phenylalanine <br /> | ||
| - | **[[2w1a]] - MtDAHPS + Mn + TSA + chorismate mutase <br /> | ||
| - | **[[3kgf]], [[3rzi]], [[5e7z]] - MtDAHPS + Mn + phenylalanine + tryptophan<br /> | ||
| - | **[[2ypq]] - MtDAHPS + Mn + tyrosine + tryptophan<br /> | ||
| - | **[[5ckx]] - MtDAHPS + Mn + tyrosine + tryptophan<br /> | ||
| - | **[[5ckv]] - EcDAHPS + chorismate mutase + TSA + Mn + phenylalanine + tryptophan + tyrosine<br /> | ||
| - | **[[5hud]] - CgDAHPS + chorismate mutase + Mn + tryptophan<br /> | ||
| - | **[[5hue]] - CgDAHPS + Mn + PEP + tryptophan<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
References
- ↑ Stephens CM, Bauerle R. Analysis of the metal requirement of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli. J Biol Chem. 1991 Nov 5;266(31):20810-7. PMID:1682314
- ↑ Shumilin IA, Zhao C, Bauerle R, Kretsinger RH. Allosteric inhibition of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase alters the coordination of both substrates. J Mol Biol. 2002 Jul 26;320(5):1147-56. PMID:12126632
