1djs

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[[Image:1djs.gif|left|200px]]
[[Image:1djs.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1djs |SIZE=350|CAPTION= <scene name='initialview01'>1djs</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1djs", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1djs| PDB=1djs | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1djs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1djs OCA], [http://www.ebi.ac.uk/pdbsum/1djs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1djs RCSB]</span>
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}}
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'''LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1'''
'''LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1'''
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[[Category: Hendrickson, W A.]]
[[Category: Hendrickson, W A.]]
[[Category: Stauber, D J.]]
[[Category: Stauber, D J.]]
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[[Category: fgf]]
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[[Category: Fgf]]
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[[Category: fgfr]]
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[[Category: Fgfr]]
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[[Category: immune system]]
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[[Category: Immune system]]
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[[Category: immunoglobulin]]
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[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:55:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:42:54 2008''
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Revision as of 10:55, 2 May 2008

Image:1djs.gif

Template:STRUCTURE 1djs

LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1


Overview

Fibroblast growth factors (FGFs) effect cellular responses by binding to FGF receptors (FGFRs). FGF bound to extracellular domains on the FGFR in the presence of heparin activates the cytoplasmic receptor tyrosine kinase through autophosphorylation. We have crystallized a complex between human FGF1 and a two-domain extracellular fragment of human FGFR2. The crystal structure, determined by multiwavelength anomalous diffraction analysis of the selenomethionyl protein, is a dimeric assemblage of 1:1 ligand:receptor complexes. FGF is bound at the junction between the two domains of one FGFR, and two such units are associated through receptor:receptor and secondary ligand:receptor interfaces. Sulfate ion positions appear to mark the course of heparin binding between FGF molecules through a basic region on receptor D2 domains. This dimeric assemblage provides a structural mechanism for FGF signal transduction.

About this Structure

1DJS is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural interactions of fibroblast growth factor receptor with its ligands., Stauber DJ, DiGabriele AD, Hendrickson WA, Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):49-54. PMID:10618369 Page seeded by OCA on Fri May 2 13:55:51 2008

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OCA

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