1ft8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1ft8.gif|left|200px]]
[[Image:1ft8.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1ft8 |SIZE=350|CAPTION= <scene name='initialview01'>1ft8</scene>, resolution 3.15&Aring;
+
The line below this paragraph, containing "STRUCTURE_1ft8", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1ft8| PDB=1ft8 | SCENE= }}
-
|RELATEDENTRY=[[1fo1|1FO1]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ft8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ft8 OCA], [http://www.ebi.ac.uk/pdbsum/1ft8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ft8 RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF THE RNA-BINDING DOMAIN OF THE MRNA EXPORT FACTOR TAP'''
'''CRYSTAL STRUCTURE OF THE RNA-BINDING DOMAIN OF THE MRNA EXPORT FACTOR TAP'''
Line 29: Line 26:
[[Category: Izaurralde, E.]]
[[Category: Izaurralde, E.]]
[[Category: Liker, E.]]
[[Category: Liker, E.]]
-
[[Category: rbd) and leucine-rich-repeat (lrr) domain]]
+
[[Category: Rrm]]
-
[[Category: ribonucleoprotein (rnp]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:44:23 2008''
-
[[Category: rrm]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:29:49 2008''
+

Revision as of 13:44, 2 May 2008

Image:1ft8.gif

Template:STRUCTURE 1ft8

CRYSTAL STRUCTURE OF THE RNA-BINDING DOMAIN OF THE MRNA EXPORT FACTOR TAP


Overview

Human TAP is implicated in mRNA nuclear export and is used by simian type D retroviruses to export their unspliced genomic RNA to the cytoplasm of the host cell. We have determined the crystal structure of the minimal TAP fragment that binds the constitutive transport element (CTE) of retroviral RNAs. Unexpectedly, we find the fragment consists of a ribonucleoprotein (RNP) domain, which is not identifiable by its sequence, and a leucine-rich repeat (LRR) domain. The non-canonical RNP domain functions as the general RNA-binding portion of the fragment. The LRR domain is required in cis to the RNP domain for CTE RNA binding. The structural and biochemical properties of the domains point to a remarkable similarity with the U2B"(RNP)-U2A'(LRR) spliceosomal heterodimer. Our in vitro and in vivo functional studies using structure-based mutants suggest that a phylogenetically conserved surface of the LRR domain of TAP may have different roles in the export of viral and cellular RNAs.

About this Structure

1FT8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain., Liker E, Fernandez E, Izaurralde E, Conti E, EMBO J. 2000 Nov 1;19(21):5587-98. PMID:11060011 Page seeded by OCA on Fri May 2 16:44:23 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/1ft8"
Personal tools