1vif

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[[Image:1vif.png|left|200px]]
 
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==STRUCTURE OF DIHYDROFOLATE REDUCTASE==
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The line below this paragraph, containing "STRUCTURE_1vif", creates the "Structure Box" on the page.
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<StructureSection load='1vif' size='340' side='right'caption='[[1vif]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1vif]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VIF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene></td></tr>
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{{STRUCTURE_1vif| PDB=1vif | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vif OCA], [https://pdbe.org/1vif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vif RCSB], [https://www.ebi.ac.uk/pdbsum/1vif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vif ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYR21_ECOLX DYR21_ECOLX] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacteria expressing R67-plasmid encoded dihydrofolate reductase (R67 DHFR) exhibit high-level resistance to the antibiotic trimethoprim. Native R67 DHFR is a 34,000 M(r) homotetramer which exists in equilibrium with an inactive dimeric form. The structure of native R67 DHFR has now been solved at 1.7 A resolution and is unrelated to that of chromosomal DHFR. Homotetrameric R67 DHFR has an unusual pore, 25 A in length, passing through the middle of the molecule. Two folate molecules bind asymmetrically within the pore indicating that the enzyme's active site consists of symmetry related binding surfaces from all four identical units.
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===STRUCTURE OF DIHYDROFOLATE REDUCTASE===
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A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site.,Narayana N, Matthews DA, Howell EE, Nguyen-huu X Nat Struct Biol. 1995 Nov;2(11):1018-25. PMID:7583655<ref>PMID:7583655</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1vif" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 7583655 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7583655}}
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==About this Structure==
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[[1vif]] is a 1 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VIF OCA].
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==See Also==
==See Also==
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*[[Dihydrofolate reductase]]
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:7583655</ref><references group="xtra"/>
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__TOC__
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[[Category: Dihydrofolate reductase]]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Howell, E E.]]
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[[Category: Large Structures]]
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[[Category: Matthews, D A.]]
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[[Category: Howell EE]]
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[[Category: Narayana, N.]]
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[[Category: Matthews DA]]
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[[Category: Xuong, N H.]]
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[[Category: Narayana N]]
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[[Category: Nadp]]
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[[Category: Xuong N-H]]
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[[Category: One-carbon metabolism]]
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[[Category: Oxidoreductase]]
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[[Category: Plasmid]]
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[[Category: Trimethoprim resistance methotrexate resistance]]
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Current revision

STRUCTURE OF DIHYDROFOLATE REDUCTASE

PDB ID 1vif

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