2a98

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[[Image:2a98.gif|left|200px]]
 
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==Crystal structure of the catalytic domain of human inositol 1,4,5-trisphosphate 3-kinase C==
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The line below this paragraph, containing "STRUCTURE_2a98", creates the "Structure Box" on the page.
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<StructureSection load='2a98' size='340' side='right'caption='[[2a98]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2a98]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A98 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
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{{STRUCTURE_2a98| PDB=2a98 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a98 OCA], [https://pdbe.org/2a98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a98 RCSB], [https://www.ebi.ac.uk/pdbsum/2a98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a98 ProSAT]</span></td></tr>
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</table>
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'''Crystal structure of the catalytic domain of human inositol 1,4,5-trisphosphate 3-kinase C'''
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== Disease ==
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[https://www.uniprot.org/uniprot/IP3KC_HUMAN IP3KC_HUMAN] Defects in ITPKC are a cause of Kawasaki disease (KWD) [MIM:[https://omim.org/entry/611775 611775]; also known as mucocutaneous lymph node syndrome or infantile polyarteritis. Kawasaki disease is an acute, self-limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy. Coronary artery aneurysms develop in 15 to 25% of those left untreated, making Kawasaki disease the leading cause of acquired heart disease among children in developed countries.<ref>PMID:18157129</ref>
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== Function ==
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==About this Structure==
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[https://www.uniprot.org/uniprot/IP3KC_HUMAN IP3KC_HUMAN] Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity).
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2A98 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A98 OCA].
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a9/2a98_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a98 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inositol-trisphosphate 3-kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Ehn M]]
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[[Category: Ehn, M.]]
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[[Category: Graslund S]]
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[[Category: Graslund, S.]]
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[[Category: Hallberg BM]]
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[[Category: Hallberg, B M.]]
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[[Category: Hammarstrom M]]
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[[Category: Hammarstrom, M.]]
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[[Category: Kotenyova T]]
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[[Category: Kotenyova, T.]]
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[[Category: Nilsson-Ehle P]]
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[[Category: Nilsson-Ehle, P.]]
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[[Category: Nordlund P]]
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[[Category: Nordlund, P.]]
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[[Category: Ogg D]]
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[[Category: Ogg, D.]]
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[[Category: Persson C]]
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[[Category: Persson, C.]]
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[[Category: Sagemark J]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Schuler H]]
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[[Category: Sagemark, J.]]
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[[Category: Stenmark P]]
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[[Category: Schuler, H.]]
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[[Category: Sundstrom M]]
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[[Category: Stenmark, P.]]
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[[Category: Thorsell A-G]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Thorsell, A G.]]
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[[Category: Weigelt, J.]]
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[[Category: Inositol]]
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[[Category: Kinase]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:46:06 2008''
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Current revision

Crystal structure of the catalytic domain of human inositol 1,4,5-trisphosphate 3-kinase C

PDB ID 2a98

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