3og9
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3og9 is ON HOLD Authors: Martinez Font, J., Mancini, S., Tauberger, E., Moniot, S. Description: Structure of YahD with Malic acid ''Page seeded by...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of YahD with Malic acid== | |
| + | <StructureSection load='3og9' size='340' side='right'caption='[[3og9]], [[Resolution|resolution]] 1.88Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3og9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis_Il1403 Lactococcus lactis subsp. lactis Il1403]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OG9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3og9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3og9 OCA], [https://pdbe.org/3og9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3og9 RCSB], [https://www.ebi.ac.uk/pdbsum/3og9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3og9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9CJC1_LACLA Q9CJC1_LACLA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Lactococcus lactis IL1403 is a lactic acid bacterium that is used widely for food fermentation. Copper homeostasis in this organism chiefly involves copper secretion by the CopA copper ATPase. This enzyme is under the control of the CopR transcriptional regulator. CopR not only controls its own expression and that of CopA, but also that of an additional three operons and two monocistronic genes. One of the genes under the control of CopR, yahD, encodes an alpha/beta-hydrolase. YahD expression was induced by copper and cadmium, but not by other metals or oxidative or nitrosative stress. The three-dimensional structure of YahD was determined by X-ray crystallography to a resolution of 1.88 A. The protein was found to adopt an alpha/beta-hydrolase fold with the characteristic Ser-His-Asp catalytic triad. Functional testing of YahD for a wide range of substrates for esterases, lipases, epoxide hydrolases, phospholipases, amidases and proteases was, however, unsuccessful. A copper-inducible serine hydrolase has not been described previously and YahD appears to be a new functional member of this enzyme family. | ||
| - | + | Regulation and structure of YahD, a copper-inducible alpha/beta serine hydrolase of Lactococcus lactis IL1403.,Martinez J, Mancini S, Tauberger E, Weise C, Saenger W, Solioz M FEMS Microbiol Lett. 2011 Jan;314(1):57-66. doi:, 10.1111/j.1574-6968.2010.02144.x. Epub 2010 Nov 9. PMID:21059179<ref>PMID:21059179</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 3og9" style="background-color:#fffaf0;"></div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Lactococcus lactis subsp. lactis Il1403]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mancini S]] | ||
| + | [[Category: Martinez Font J]] | ||
| + | [[Category: Moniot S]] | ||
| + | [[Category: Tauberger E]] | ||
Current revision
Structure of YahD with Malic acid
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