4zjs

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==Crystal structure of a chimeric acetylcholine binding protein from Aplysia Californica (Ac-AChBP) containing the main immunogenic region (MIR) from the human alpha 1 subunit of the muscle nicotinic acetylcholine receptor in complex with anatoxin-A.==
==Crystal structure of a chimeric acetylcholine binding protein from Aplysia Californica (Ac-AChBP) containing the main immunogenic region (MIR) from the human alpha 1 subunit of the muscle nicotinic acetylcholine receptor in complex with anatoxin-A.==
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<StructureSection load='4zjs' size='340' side='right' caption='[[4zjs]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
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<StructureSection load='4zjs' size='340' side='right'caption='[[4zjs]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zjs]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZJS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zjs]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZJS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4P0:1-[(1R,6R)-9-AZABICYCLO[4.2.1]NON-2-EN-2-YL]ETHANONE'>4P0</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2301&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zjs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zjs RCSB], [http://www.ebi.ac.uk/pdbsum/4zjs PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4P0:1-[(1R,6R)-9-AZABICYCLO[4.2.1]NON-2-EN-2-YL]ETHANONE'>4P0</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zjs OCA], [https://pdbe.org/4zjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zjs RCSB], [https://www.ebi.ac.uk/pdbsum/4zjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zjs ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/ACHA_HUMAN ACHA_HUMAN]] Postsynaptic congenital myasthenic syndromes;Lethal multiple pterygium syndrome. The disease is caused by mutations affecting the gene represented in this entry. The alpha subunit is the main focus for antibody binding in myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/ACHA_HUMAN ACHA_HUMAN] Postsynaptic congenital myasthenic syndromes;Lethal multiple pterygium syndrome. The disease is caused by mutations affecting the gene represented in this entry. The alpha subunit is the main focus for antibody binding in myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACHA_HUMAN ACHA_HUMAN]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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[https://www.uniprot.org/uniprot/Q8WSF8_APLCA Q8WSF8_APLCA] [https://www.uniprot.org/uniprot/ACHA_HUMAN ACHA_HUMAN] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4zjs" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Acetylcholine binding protein 3D structures|Acetylcholine binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bobango, J]]
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[[Category: Aplysia californica]]
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[[Category: Lindsatrom, J]]
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[[Category: Homo sapiens]]
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[[Category: Luo, J]]
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[[Category: Large Structures]]
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[[Category: Park, J F]]
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[[Category: Bobango J]]
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[[Category: Talley, T T]]
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[[Category: Lindsatrom J]]
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[[Category: Taylor, P]]
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[[Category: Luo J]]
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[[Category: Wu, J]]
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[[Category: Park JF]]
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[[Category: Acetylcholine]]
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[[Category: Talley TT]]
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[[Category: Anatoxin-a]]
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[[Category: Taylor P]]
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[[Category: Immune system]]
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[[Category: Wu J]]
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[[Category: Nicotinic]]
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[[Category: Receptor]]
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Current revision

Crystal structure of a chimeric acetylcholine binding protein from Aplysia Californica (Ac-AChBP) containing the main immunogenic region (MIR) from the human alpha 1 subunit of the muscle nicotinic acetylcholine receptor in complex with anatoxin-A.

PDB ID 4zjs

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OCA

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