5nip
From Proteopedia
(Difference between revisions)
m (Protected "5nip" [edit=sysop:move=sysop]) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==An i-motif containing the neutral cytidine protonated analogue pseudoisocytidine== | |
| + | <StructureSection load='5nip' size='340' side='right'caption='[[5nip]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5nip]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NIP FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8YN:Pseudoisocytidine'>8YN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nip OCA], [https://pdbe.org/5nip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nip RCSB], [https://www.ebi.ac.uk/pdbsum/5nip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nip ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Incorporation of pseudoisocytidine (psC), a neutral analogue of protonated cytidine, in i-motifs has been studied by spectroscopic methods. Our results show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the stabilization only occurs when psC:C base pairs are located at the ends of intercalated C:C+ stacks. When psC occupies central positions, the resulting i-motifs are only observed at low pH and psC:C+ or psC:psC+ hemiprotonated base pairs are formed instead of their neutral analogs. Overall, our results suggest that positively charged base pairs are necessary to stabilize this non-canonical DNA structure. | ||
| - | + | The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures.,Mir B, Soles X, Gonzalez C, Escaja N Sci Rep. 2017 Jun 5;7(1):2772. doi: 10.1038/s41598-017-02723-y. PMID:28584239<ref>PMID:28584239</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5nip" style="background-color:#fffaf0;"></div> |
| - | [[Category: Gonzalez | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Escaja N]] | ||
| + | [[Category: Gonzalez C]] | ||
| + | [[Category: Mir B]] | ||
| + | [[Category: Soles X]] | ||
Current revision
An i-motif containing the neutral cytidine protonated analogue pseudoisocytidine
| |||||||||||
