4u4c

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==The molecular architecture of the TRAMP complex reveals the organization and interplay of its two catalytic activities==
==The molecular architecture of the TRAMP complex reveals the organization and interplay of its two catalytic activities==
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<StructureSection load='4u4c' size='340' side='right' caption='[[4u4c]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4u4c' size='340' side='right'caption='[[4u4c]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4u4c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U4C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4u4c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U4C FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u4c RCSB], [http://www.ebi.ac.uk/pdbsum/4u4c PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4c OCA], [https://pdbe.org/4u4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u4c RCSB], [https://www.ebi.ac.uk/pdbsum/4u4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u4c ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTR4_YEAST MTR4_YEAST] ATP-dependent RNA helicase required for the 3'-end formation of 5.8S RNA. Cofactor for the exosome complex that unwinds secondary structure in pre-rRNA. Required for nucleocytoplasmic transport of mRNA. May serve as a chaperone which translocates or normalizes the structure of mRNAs in preparation for export. Component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates.<ref>PMID:15828860</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4u4c" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Helicase 3D structures|Helicase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: RNA helicase]]
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[[Category: Large Structures]]
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[[Category: Bonneau, F.]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Conti, E.]]
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[[Category: Bonneau F]]
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[[Category: Falk, S.]]
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[[Category: Conti E]]
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[[Category: Hentschel, J.]]
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[[Category: Falk S]]
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[[Category: Reichelt, P.]]
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[[Category: Hentschel J]]
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[[Category: Weir, J R.]]
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[[Category: Reichelt P]]
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[[Category: Atpase]]
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[[Category: Weir JR]]
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[[Category: Exosome]]
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[[Category: Helicase]]
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[[Category: Hydrolase]]
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[[Category: Rna degradation]]
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Current revision

The molecular architecture of the TRAMP complex reveals the organization and interplay of its two catalytic activities

PDB ID 4u4c

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