2f6h

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[[Image:2f6h.png|left|200px]]
 
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{{STRUCTURE_2f6h| PDB=2f6h | SCENE= }}
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==Myosin V cargo binding domain==
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<StructureSection load='2f6h' size='340' side='right'caption='[[2f6h]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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===Myosin V cargo binding domain===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2f6h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F6H FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16437158}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f6h OCA], [https://pdbe.org/2f6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f6h RCSB], [https://www.ebi.ac.uk/pdbsum/2f6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f6h ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[2f6h]] is a 1 chain structure of [[Myosin]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F6H OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/MYO2_YEAST MYO2_YEAST] Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Essential for the delivery of secretory vesicles to sites of active growth during bud emergence and cytokinesis. Required for segregation and inheritance of peroxisomes, late Golgi compartments, mitochondria and the vacuole to the daughter cell during cell division. Also required for correct alignment of the spindle during mitosis.<ref>PMID:10931864</ref> <ref>PMID:11285273</ref> <ref>PMID:11381095</ref> <ref>PMID:11733545</ref> <ref>PMID:11781333</ref> <ref>PMID:12391144</ref> <ref>PMID:12743102</ref> <ref>PMID:21248204</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/2f6h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f6h ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Myosin|Myosin]]
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*[[Myosin 3D Structures|Myosin 3D Structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016437158</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Jin, Y.]]
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[[Category: Jin Y]]
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[[Category: Pashkova, N.]]
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[[Category: Pashkova N]]
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[[Category: Ramaswamy, S.]]
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[[Category: Ramaswamy S]]
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[[Category: Weisman, L S.]]
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[[Category: Weisman LS]]
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[[Category: Cargo binding]]
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[[Category: Cargo transport]]
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[[Category: Mysoin v]]
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[[Category: Secreatory vescile binding]]
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[[Category: Structural protein]]
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[[Category: Vacuole binding]]
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Current revision

Myosin V cargo binding domain

PDB ID 2f6h

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Proteopedia Page Contributors and Editors (what is this?)

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