1ihm

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[[Image:1ihm.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID==
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|PDB= 1ihm |SIZE=350|CAPTION= <scene name='initialview01'>1ihm</scene>, resolution 3.4&Aring;
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<StructureSection load='1ihm' size='340' side='right'caption='[[1ihm]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1ihm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IHM FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ihm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ihm OCA], [https://pdbe.org/1ihm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ihm RCSB], [https://www.ebi.ac.uk/pdbsum/1ihm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ihm ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAPSD_NVN68 CAPSD_NVN68] Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding histo-blood group antigens present on gastroduodenal epithelial cells.<ref>PMID:16840313</ref> Soluble capsid protein may play a role in viral immunoevasion.<ref>PMID:16840313</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/1ihm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ihm ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID'''
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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==Overview==
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<references/>
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Norwalk virus, a noncultivatable human calicivirus, is the major cause of epidemic gastroenteritis in humans. The first x-ray structure of a calicivirus capsid, which consists of 180 copies of a single protein, has been determined by phase extension from a low-resolution electron microscopy structure. The capsid protein has a protruding (P) domain connected by a flexible hinge to a shell (S) domain that has a classical eight-stranded beta-sandwich motif. The structure of the P domain is unlike that of any other viral protein with a subdomain exhibiting a fold similar to that of the second domain in the eukaryotic translation elongation factor-Tu. This subdomain, located at the exterior of the capsid, has the largest sequence variation among Norwalk-like human caliciviruses and is likely to contain the determinants of strain specificity and cell binding.
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1IHM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHM OCA].
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==Reference==
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X-ray crystallographic structure of the Norwalk virus capsid., Prasad BV, Hardy ME, Dokland T, Bella J, Rossmann MG, Estes MK, Science. 1999 Oct 8;286(5438):287-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10514371 10514371]
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[[Category: Norwalk virus]]
[[Category: Norwalk virus]]
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[[Category: Single protein]]
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[[Category: Bella J]]
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[[Category: Bella, J.]]
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[[Category: Dokland T]]
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[[Category: Dokland, T.]]
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[[Category: Estes MK]]
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[[Category: Estes, M K.]]
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[[Category: Hardy ME]]
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[[Category: Hardy, M E.]]
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[[Category: Prasad BV]]
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[[Category: Prasad, B V.]]
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[[Category: Rossmann MG]]
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[[Category: Rossmann, M G.]]
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[[Category: beta-barrel]]
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[[Category: ef-tu-like domain caliciviridae]]
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[[Category: icosahedral virus]]
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[[Category: t=3 icosahedral capsid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:50:27 2008''
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Current revision

CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID

PDB ID 1ihm

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