2l0x

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{{Seed}}
 
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[[Image:2l0x.png|left|200px]]
 
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==Solution structure of the 21 kDa GTPase RHEB bound to GDP==
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The line below this paragraph, containing "STRUCTURE_2l0x", creates the "Structure Box" on the page.
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<StructureSection load='2l0x' size='340' side='right'caption='[[2l0x]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l0x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0X FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2l0x| PDB=2l0x | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0x OCA], [https://pdbe.org/2l0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0x RCSB], [https://www.ebi.ac.uk/pdbsum/2l0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RHEB_RAT RHEB_RAT] Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/2l0x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2l0x ConSurf].
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<div style="clear:both"></div>
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===Solution structure of the 21 kDa GTPase RHEB bound to GDP===
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_20685651}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20685651 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20685651}}
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==About this Structure==
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2L0X is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0X OCA].
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==Reference==
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<ref group="xtra">PMID:20685651</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Berghaus, C.]]
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[[Category: Berghaus C]]
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[[Category: Heumann, R.]]
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[[Category: Heumann R]]
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[[Category: Kock, G.]]
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[[Category: Kock G]]
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[[Category: Stoll, R.]]
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[[Category: Stoll R]]
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[[Category: Gtpase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:24:17 2010''
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Current revision

Solution structure of the 21 kDa GTPase RHEB bound to GDP

PDB ID 2l0x

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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