2mj2
From Proteopedia
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| - | {{STRUCTURE_2mj2| PDB=2mj2 | SCENE= }} | ||
| - | ===Structure of the dimerization domain of the human polyoma, JC virus agnoprotein is an amphipathic alpha-helix.=== | ||
| - | {{ABSTRACT_PUBMED_23747198}} | ||
| - | == | + | ==Structure of the dimerization domain of the human polyoma, JC virus agnoprotein is an amphipathic alpha-helix.== |
| - | [[http://www.uniprot.org/uniprot/AGNO_POVJC AGNO_POVJC | + | <StructureSection load='2mj2' size='340' side='right'caption='[[2mj2]]' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[2mj2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/JC_polyomavirus JC polyomavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJ2 FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mj2 OCA], [https://pdbe.org/2mj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mj2 RCSB], [https://www.ebi.ac.uk/pdbsum/2mj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mj2 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/AGNO_POVJC AGNO_POVJC] Alters the structure of the nuclear envelope by interacting with host CBX5 and disrupting CBX5 association with LBR. Involved in the perinuclear-nuclear localization of the capsid protein VP1 during virion assembly and maturation. Plays an important role in the release of progeny virions from infected cells and in viral propagation, probably by acting as a viral ionic channel in the host plasma membrane. Allows influx of extracellular calcium ions in the host cell. May contribute to viral genome transcription and translation of viral late proteins.<ref>PMID:11517407</ref> <ref>PMID:12165856</ref> <ref>PMID:20300659</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[Category: | + | [[Category: JC polyomavirus]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Abou-Gharbia M]] |
| - | [[Category: | + | [[Category: Bouaziz S]] |
| - | [[Category: | + | [[Category: Childers W]] |
| - | [[Category: | + | [[Category: Coric P]] |
| - | + | [[Category: Safak M]] | |
| + | [[Category: Saribas SA]] | ||
| + | [[Category: White M]] | ||
Current revision
Structure of the dimerization domain of the human polyoma, JC virus agnoprotein is an amphipathic alpha-helix.
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