2ib1

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[[Image:2ib1.jpg|left|200px]]
 
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{{Structure
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==Solution structure of p45 Death Domain==
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|PDB= 2ib1 |SIZE=350|CAPTION= <scene name='initialview01'>2ib1</scene>
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<StructureSection load='2ib1' size='340' side='right'caption='[[2ib1]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2ib1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IB1 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= Nradd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ib1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ib1 OCA], [https://pdbe.org/2ib1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ib1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ib1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ib1 ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''Solution structure of p45 Death Domain'''
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[https://www.uniprot.org/uniprot/NRADD_MOUSE NRADD_MOUSE] Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR.<ref>PMID:12728256</ref> <ref>PMID:12843241</ref> <ref>PMID:19407813</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2IB1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IB1 OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ib/2ib1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ib1 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Lee KF]]
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[[Category: Lee, K F.]]
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[[Category: Riek R]]
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[[Category: Riek, R.]]
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[[Category: Sung TC]]
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[[Category: Sung, T C.]]
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[[Category: Vilar M]]
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[[Category: Vilar, M.]]
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[[Category: apoptosis]]
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[[Category: death domain]]
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[[Category: fadd]]
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[[Category: nogo]]
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[[Category: p45]]
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[[Category: p75]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:27:22 2008''
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Current revision

Solution structure of p45 Death Domain

PDB ID 2ib1

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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