2ib1

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[[Image:2ib1.jpg|left|200px]]
 
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==Solution structure of p45 Death Domain==
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The line below this paragraph, containing "STRUCTURE_2ib1", creates the "Structure Box" on the page.
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<StructureSection load='2ib1' size='340' side='right'caption='[[2ib1]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ib1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IB1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ib1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ib1 OCA], [https://pdbe.org/2ib1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ib1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ib1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ib1 ProSAT]</span></td></tr>
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{{STRUCTURE_2ib1| PDB=2ib1 | SCENE= }}
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</table>
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== Function ==
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'''Solution structure of p45 Death Domain'''
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[https://www.uniprot.org/uniprot/NRADD_MOUSE NRADD_MOUSE] Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR.<ref>PMID:12728256</ref> <ref>PMID:12843241</ref> <ref>PMID:19407813</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2IB1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IB1 OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ib/2ib1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ib1 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Lee KF]]
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[[Category: Lee, K F.]]
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[[Category: Riek R]]
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[[Category: Riek, R.]]
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[[Category: Sung TC]]
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[[Category: Sung, T C.]]
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[[Category: Vilar M]]
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[[Category: Vilar, M.]]
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[[Category: Apoptosis]]
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[[Category: Death domain]]
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[[Category: Fadd]]
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[[Category: Nogo]]
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[[Category: P45]]
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[[Category: P75]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:16:58 2008''
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Current revision

Solution structure of p45 Death Domain

PDB ID 2ib1

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Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/2ib1"
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