1cvs

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{{Seed}}
 
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[[Image:1cvs.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1cvs", creates the "Structure Box" on the page.
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<StructureSection load='1cvs' size='340' side='right'caption='[[1cvs]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1cvs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CVS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1cvs| PDB=1cvs | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cvs OCA], [https://pdbe.org/1cvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cvs RCSB], [https://www.ebi.ac.uk/pdbsum/1cvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cvs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FGF2_HUMAN FGF2_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:1721615</ref> <ref>PMID:8663044</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cv/1cvs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cvs ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of FGF2 bound to a naturally occurring variant of FGF receptor 1 (FGFR1) consisting of immunoglobulin-like domains 2 (D2) and 3 (D3) has been determined at 2.8 A resolution. Two FGF2:FGFR1 complexes form a 2-fold symmetric dimer. Within each complex, FGF2 interacts extensively with D2 and D3 as well as with the linker between the two domains. The dimer is stabilized by interactions between FGF2 and D2 of the adjoining complex and by a direct interaction between D2 of each receptor. A positively charged canyon formed by a cluster of exposed basic residues likely represents the heparin-binding site. A general model for FGF- and heparin-induced FGFR dimerization is inferred from the crystal structure, unifying a wealth of biochemical data.
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===CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX===
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Structural basis for FGF receptor dimerization and activation.,Plotnikov AN, Schlessinger J, Hubbard SR, Mohammadi M Cell. 1999 Sep 3;98(5):641-50. PMID:10490103<ref>PMID:10490103</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1cvs" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_10490103}}, adds the Publication Abstract to the page
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*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10490103 is the PubMed ID number.
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*[[Fibroblast growth factor receptor 3D receptor|Fibroblast growth factor receptor 3D receptor]]
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== References ==
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{{ABSTRACT_PUBMED_10490103}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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1CVS is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVS OCA].
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==Reference==
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<ref group="xtra">PMID:10490103</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hubbard, S R.]]
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[[Category: Large Structures]]
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[[Category: Mohammadi, M.]]
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[[Category: Hubbard SR]]
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[[Category: Plotnikov, A N.]]
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[[Category: Mohammadi M]]
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[[Category: Schlessinger, J.]]
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[[Category: Plotnikov AN]]
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[[Category: Dimerization]]
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[[Category: Schlessinger J]]
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[[Category: Fgf]]
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[[Category: Fgfr]]
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[[Category: Immunoglobulin-like]]
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[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:06:41 2009''
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Current revision

CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX

PDB ID 1cvs

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