9ksq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the mouse Shank3 SAM domain== | |
| - | + | <StructureSection load='9ksq' size='340' side='right'caption='[[9ksq]], [[Resolution|resolution]] 2.79Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9ksq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KSQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.79Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ksq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ksq OCA], [https://pdbe.org/9ksq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ksq RCSB], [https://www.ebi.ac.uk/pdbsum/9ksq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ksq ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Mingjie | + | == Function == |
| + | [https://www.uniprot.org/uniprot/SHAN3_MOUSE SHAN3_MOUSE] Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.<ref>PMID:21423165</ref> <ref>PMID:21558424</ref> <ref>PMID:23739967</ref> <ref>PMID:24153177</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Mingjie Z]] | ||
| + | [[Category: Zeyu S]] | ||
Current revision
Crystal Structure of the mouse Shank3 SAM domain
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