1djs

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[[Image:1djs.gif|left|200px]]
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{{Seed}}
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[[Image:1djs.png|left|200px]]
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{{STRUCTURE_1djs| PDB=1djs | SCENE= }}
{{STRUCTURE_1djs| PDB=1djs | SCENE= }}
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'''LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1'''
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===LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1===
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==Overview==
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Fibroblast growth factors (FGFs) effect cellular responses by binding to FGF receptors (FGFRs). FGF bound to extracellular domains on the FGFR in the presence of heparin activates the cytoplasmic receptor tyrosine kinase through autophosphorylation. We have crystallized a complex between human FGF1 and a two-domain extracellular fragment of human FGFR2. The crystal structure, determined by multiwavelength anomalous diffraction analysis of the selenomethionyl protein, is a dimeric assemblage of 1:1 ligand:receptor complexes. FGF is bound at the junction between the two domains of one FGFR, and two such units are associated through receptor:receptor and secondary ligand:receptor interfaces. Sulfate ion positions appear to mark the course of heparin binding between FGF molecules through a basic region on receptor D2 domains. This dimeric assemblage provides a structural mechanism for FGF signal transduction.
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The line below this paragraph, {{ABSTRACT_PUBMED_10618369}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10618369 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10618369}}
==About this Structure==
==About this Structure==
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[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:55:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:10:29 2008''

Revision as of 20:10, 30 June 2008

Image:1djs.png

Template:STRUCTURE 1djs

LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1

Template:ABSTRACT PUBMED 10618369

About this Structure

1DJS is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural interactions of fibroblast growth factor receptor with its ligands., Stauber DJ, DiGabriele AD, Hendrickson WA, Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):49-54. PMID:10618369

Page seeded by OCA on Mon Jun 30 23:10:29 2008

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