1g2h

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{{STRUCTURE_1g2h| PDB=1g2h | SCENE= }}
{{STRUCTURE_1g2h| PDB=1g2h | SCENE= }}
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'''SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF THE TYRR PROTEIN OF HAEMOPHILUS INFLUENZAE'''
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===SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF THE TYRR PROTEIN OF HAEMOPHILUS INFLUENZAE===
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==Overview==
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The TyrR protein of Haemophilus influenzae is a 36-kD transcription factor whose major function is to control the expression of genes important in the biosynthesis and transport of aromatic amino acids. Using (1)H and (15)N NMR spectroscopy, we have determined the 3D solution structure of the TyrR C-terminal DNA-binding domain (DBD) containing residues from 258 to 318 (TyrR[258-318]). The NMR results show that this segment of TyrR consists of a potential hinge helix at its N terminus (residues 263-270) as well as three well-defined alpha-helices extending from residues 277-289 (HR-2), 293-300 (HR-1), and 304-314 (HR). Helix HR-1 and HR fold in a typical helix-turn-helix (HTH) motif. The three helices and the hinge helix are tightly bound together by hydrophobic interaction and hydrogen bonds. Several hydrophilic residues whose side chains may directly interact with DNA are identified. A hydrophobic patch that may be part of the interaction surface between the domains of TyrR protein is also observed. Comparisons with the structures of other HTH DNA-binding proteins reveal that in terms of the spatial orientation of the three helices, this protein most closely resembles the cap family.
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{{ABSTRACT_PUBMED_11344327}}
==About this Structure==
==About this Structure==
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1G2H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G2H OCA].
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1G2H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G2H OCA].
==Reference==
==Reference==
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[[Category: Protein structure]]
[[Category: Protein structure]]
[[Category: Tyrr]]
[[Category: Tyrr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:18:37 2008''

Revision as of 01:18, 1 July 2008

Image:1g2h.png

Template:STRUCTURE 1g2h

SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF THE TYRR PROTEIN OF HAEMOPHILUS INFLUENZAE

Template:ABSTRACT PUBMED 11344327

About this Structure

1G2H is a Single protein structure of sequence from Haemophilus influenzae. Full experimental information is available from OCA.

Reference

Solution structure of the DNA-binding domain of the TyrR protein of Haemophilus influenzae., Wang Y, Zhao S, Somerville RL, Jardetzky O, Protein Sci. 2001 Mar;10(3):592-8. PMID:11344327

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