1hwu

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{{STRUCTURE_1hwu| PDB=1hwu | SCENE= }}
{{STRUCTURE_1hwu| PDB=1hwu | SCENE= }}
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'''STRUCTURE OF PII PROTEIN FROM HERBASPIRILLUM SEROPEDICAE'''
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===STRUCTURE OF PII PROTEIN FROM HERBASPIRILLUM SEROPEDICAE===
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==Overview==
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PII-like proteins are signal transduction proteins found in bacteria, archaea and eukaryotes. They mediate a variety of cellular responses. A second PII-like protein, called GlnK, has been found in several organisms. In the diazotroph Herbaspirillum seropedicae, PII protein is involved in sensing nitrogen levels and controlling nitrogen fixation genes. In this work, the crystal structure of the unliganded H. seropedicae PII was solved by X-ray diffraction. H. seropedicae PII has a Gly residue, Gly108 preceding Pro109 and the main-chain forms a beta turn. The glycine at position 108 allows a bend in the C-terminal main-chain, thereby modifying the surface of the cleft between monomers and potentially changing function. The structure suggests that the C-terminal region of PII proteins may be involved in specificity of function, and nonenteric diazotrophs are found to have the C-terminal consensus XGXDAX(107-112). We are also proposing binding sites for ATP and 2-oxoglutarate based on the structural alignment of PII with PII-ATP/GlnK-ATP, 5-carboxymethyl-2-hydroxymuconate isomerase and 4-oxalocrotonate tautomerase bound to the inhibitor 2-oxo-3-pentynoate.
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{{ABSTRACT_PUBMED_12084071}}
==About this Structure==
==About this Structure==
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[[Category: Herbaspirillum seropedicae pii]]
[[Category: Herbaspirillum seropedicae pii]]
[[Category: Signal transduction protein]]
[[Category: Signal transduction protein]]
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Revision as of 07:02, 1 July 2008

Image:1hwu.png

Template:STRUCTURE 1hwu

STRUCTURE OF PII PROTEIN FROM HERBASPIRILLUM SEROPEDICAE

Template:ABSTRACT PUBMED 12084071

About this Structure

1HWU is a Single protein structure of sequence from Herbaspirillum seropedicae. Full crystallographic information is available from OCA.

Reference

Herbaspirillum seropedicae signal transduction protein PII is structurally similar to the enteric GlnK., Machado Benelli E, Buck M, Polikarpov I, Maltempi de Souza E, Cruz LM, Pedrosa FO, Eur J Biochem. 2002 Jul;269(13):3296-303. PMID:12084071

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