1kek

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1kek.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1kek.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1kek| PDB=1kek | SCENE= }}
{{STRUCTURE_1kek| PDB=1kek | SCENE= }}
-
'''Crystal Structure of the Free Radical Intermediate of Pyruvate:Ferredoxin Oxidoreductase'''
+
===Crystal Structure of the Free Radical Intermediate of Pyruvate:Ferredoxin Oxidoreductase===
-
==Overview==
+
<!--
-
In anaerobic organisms, the decarboxylation of pyruvate, a crucial component of intermediary metabolism, is catalyzed by the metalloenzyme pyruvate: ferredoxin oxidoreductase (PFOR) resulting in the generation of low potential electrons and the subsequent acetylation of coenzyme A (CoA). PFOR is the only enzyme for which a stable acetyl thiamine diphosphate (ThDP)-based free radical reaction intermediate has been identified. The 1.87 A-resolution structure of the radical form of PFOR from Desulfovibrio africanus shows that, despite currently accepted ideas, the thiazole ring of the ThDP cofactor is markedly bent, indicating a drastic reduction of its aromaticity. In addition, the bond connecting the acetyl group to ThDP is unusually long, probably of the one-electron type already described for several cation radicals but not yet found in a biological system. Taken together, our data, along with evidence from the literature, suggest that acetyl-CoA synthesis by PFOR proceeds via a condensation mechanism involving acetyl (PFOR-based) and thiyl (CoA-based) radicals.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11752578}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11752578 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11752578}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: 7 domain]]
[[Category: 7 domain]]
[[Category: Homodimer]]
[[Category: Homodimer]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:38:49 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:13:21 2008''

Revision as of 07:13, 2 July 2008

Image:1kek.png

Template:STRUCTURE 1kek

Crystal Structure of the Free Radical Intermediate of Pyruvate:Ferredoxin Oxidoreductase

Template:ABSTRACT PUBMED 11752578

About this Structure

1KEK is a Single protein structure of sequence from Desulfovibrio africanus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase., Chabriere E, Vernede X, Guigliarelli B, Charon MH, Hatchikian EC, Fontecilla-Camps JC, Science. 2001 Dec 21;294(5551):2559-63. PMID:11752578

Page seeded by OCA on Wed Jul 2 10:13:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/1kek"
Personal tools