1v5w

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[[Image:1v5w.gif|left|200px]]
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{{STRUCTURE_1v5w| PDB=1v5w | SCENE= }}
{{STRUCTURE_1v5w| PDB=1v5w | SCENE= }}
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'''Crystal structure of the human Dmc1 protein'''
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===Crystal structure of the human Dmc1 protein===
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==Overview==
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The human Dmc1 protein, a RecA/Rad51 homolog, is a meiosis-specific DNA recombinase that catalyzes homologous pairing. RecA and Rad51 form helical filaments, while Dmc1 forms an octameric ring. In the present study, we crystallized the full-length human Dmc1 protein and solved the structure of the Dmc1 octameric ring. The monomeric structure of the Dmc1 protein closely resembled those of the human and archaeal Rad51 proteins. In addition to the polymerization motif that was previously identified in the Rad51 proteins, we found another hydrogen bonding interaction at the polymer interface, which could explain why Dmc1 forms stable octameric rings instead of helical filaments. Mutagenesis studies identified the inner and outer basic patches that are important for homologous pairing. The inner patch binds both single-stranded and double-stranded DNAs, while the outer one binds single-stranded DNA. Based on these results, we propose a model for the interaction of the Dmc1 rings with DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 15125839 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15125839}}
==About this Structure==
==About this Structure==
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[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:07:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:31:35 2008''

Revision as of 13:31, 27 July 2008

Image:1v5w.png

Template:STRUCTURE 1v5w

Crystal structure of the human Dmc1 protein

Template:ABSTRACT PUBMED 15125839

About this Structure

1V5W is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1., Kinebuchi T, Kagawa W, Enomoto R, Tanaka K, Miyagawa K, Shibata T, Kurumizaka H, Yokoyama S, Mol Cell. 2004 May 7;14(3):363-74. PMID:15125839

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