2jwt

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{{STRUCTURE_2jwt| PDB=2jwt | SCENE= }}
{{STRUCTURE_2jwt| PDB=2jwt | SCENE= }}
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'''Solution structure of Engrailed homeodomain WT'''
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===Solution structure of Engrailed homeodomain WT===
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==Overview==
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Two methods are currently available to solve high resolution protein structures-X-ray crystallography and nuclear magnetic resonance (NMR). Both methods usually produce highly similar structures, but small differences between both solutions are always observed. Here the raw NMR data as well as the solved NMR structure were compared to the multiple crystal structures solved for the WT 60 residue three helix bundle engrailed homeodomain (EnHD) and single point mutants. There was excellent agreement between TALOS-predicted and crystal structure-observed dihedral angles and a good agreement for the (3) J(H ( N ) H ( alpha )) couplings for the multiple crystal structures. Around 1% of NOEs were violated for any crystal structure, but no NOE was inconsistent with all of the crystal structures. Violations usually occurred for surface residues or for residues for which multiple discreet conformations were observed between the crystal structures. Comparison of the disorder shown in the multiple crystal structures shows little correlation with dynamics under native conditions for this protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 18274703 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18274703}}
==About this Structure==
==About this Structure==
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2JWT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWT OCA].
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2JWT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWT OCA].
==Reference==
==Reference==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:21:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:45:27 2008''

Revision as of 23:45, 27 July 2008

Image:2jwt.png

Template:STRUCTURE 2jwt

Solution structure of Engrailed homeodomain WT

Template:ABSTRACT PUBMED 18274703

About this Structure

2JWT is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

Comparison of multiple crystal structures with NMR data for engrailed homeodomain., Religa TL, J Biomol NMR. 2008 Mar;40(3):189-202. Epub 2008 Feb 15. PMID:18274703

Page seeded by OCA on Mon Jul 28 02:45:27 2008

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