2rfh

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{{STRUCTURE_2rfh| PDB=2rfh | SCENE= }}
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'''Crystal Structure Analysis of CPA-2-benzyl-3-nitropropanoic acid complex'''
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===Crystal Structure Analysis of CPA-2-benzyl-3-nitropropanoic acid complex===
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==Overview==
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2-Substituted 3-nitropropanoic acids were designed and synthesized as inhibitors against carboxypeptidase A (CPA). (R)-2-Benzyl- 3-nitropropanoic acid showed a potent inhibition against CPA (K(i)=0.15 microM). X-ray crystallography discloses that the nitro group well mimics the transition state occurred in the hydrolysis catalyzed by CPA, that is, an O,O'-bidentate coordination to the zinc ion and the two respective hydrogen bonds with Glu-270 and Arg-127. Because the nitro group is a planar species, we proposed (R)-2-benzyl-3-nitropropanoic acid as a pseudo-transition-state analog inhibitor against CPA.
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==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:23:34 2008''

Revision as of 01:23, 28 July 2008

Image:2rfh.png

Template:STRUCTURE 2rfh

Crystal Structure Analysis of CPA-2-benzyl-3-nitropropanoic acid complex

Template:ABSTRACT PUBMED 18289863

About this Structure

2RFH is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Nitro as a novel zinc-binding group in the inhibition of carboxypeptidase A., Wang SH, Wang SF, Xuan W, Zeng ZH, Jin JY, Ma J, Tian GR, Bioorg Med Chem. 2008 Apr 1;16(7):3596-601. Epub 2008 Feb 8. PMID:18289863

Page seeded by OCA on Mon Jul 28 04:23:34 2008

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