1zcd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1zcd.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1zcd.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1zcd| PDB=1zcd | SCENE= }}
{{STRUCTURE_1zcd| PDB=1zcd | SCENE= }}
-
'''Crystal structure of the Na+/H+ antiporter NhaA'''
+
===Crystal structure of the Na+/H+ antiporter NhaA===
-
==Overview==
+
<!--
-
The control by Na+/H+ antiporters of sodium/proton concentration and cell volume is crucial for the viability of all cells. Adaptation to high salinity and/or extreme pH in plants and bacteria or in human heart muscles requires the action of Na+/H+ antiporters. Their activity is tightly controlled by pH. Here we present the crystal structure of pH-downregulated NhaA, the main antiporter of Escherichia coli and many enterobacteria. A negatively charged ion funnel opens to the cytoplasm and ends in the middle of the membrane at the putative ion-binding site. There, a unique assembly of two pairs of short helices connected by crossed, extended chains creates a balanced electrostatic environment. We propose that the binding of charged substrates causes an electric imbalance, inducing movements, that permit a rapid alternating-access mechanism. This ion-exchange machinery is regulated by a conformational change elicited by a pH signal perceived at the entry to the cytoplasmic funnel.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15988517}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15988517 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15988517}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Antiporter]]
[[Category: Antiporter]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:27:29 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:22:09 2008''

Revision as of 01:22, 29 July 2008

Image:1zcd.png

Template:STRUCTURE 1zcd

Crystal structure of the Na+/H+ antiporter NhaA

Template:ABSTRACT PUBMED 15988517

About this Structure

1ZCD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH., Hunte C, Screpanti E, Venturi M, Rimon A, Padan E, Michel H, Nature. 2005 Jun 30;435(7046):1197-202. PMID:15988517

Page seeded by OCA on Tue Jul 29 04:22:09 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/1zcd"
Personal tools