3llh

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[[Image:3llh.jpg|left|200px]]
 
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==Crystal structure of the first dsRBD of TAR RNA-binding protein 2==
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The line below this paragraph, containing "STRUCTURE_3llh", creates the "Structure Box" on the page.
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<StructureSection load='3llh' size='340' side='right'caption='[[3llh]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3llh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LLH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LLH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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{{STRUCTURE_3llh| PDB=3llh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3llh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3llh OCA], [https://pdbe.org/3llh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3llh RCSB], [https://www.ebi.ac.uk/pdbsum/3llh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3llh ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the first dsRBD of TAR RNA-binding protein 2===
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== Function ==
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[https://www.uniprot.org/uniprot/TRBP2_HUMAN TRBP2_HUMAN] Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.<ref>PMID:12475984</ref> <ref>PMID:16271387</ref> <ref>PMID:16142218</ref> <ref>PMID:16357216</ref> <ref>PMID:15973356</ref> <ref>PMID:16424907</ref> <ref>PMID:17452327</ref> <ref>PMID:18178619</ref> <ref>PMID:19219043</ref>
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== References ==
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==About this Structure==
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<references/>
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3LLH is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LLH OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kawazoe, M.]]
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[[Category: Large Structures]]
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[[Category: Sekine, S.]]
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[[Category: Kawazoe M]]
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[[Category: Takemoto, C.]]
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[[Category: Sekine S]]
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[[Category: Wakiyama, M.]]
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[[Category: Takemoto C]]
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[[Category: Yamashita, S.]]
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[[Category: Wakiyama M]]
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[[Category: Yokoyama, S.]]
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[[Category: Yamashita S]]
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[[Category: Dsrbd]]
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[[Category: Yokoyama S]]
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[[Category: Dsrm]]
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[[Category: Microrna]]
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[[Category: Rna binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:49:15 2010''
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Current revision

Crystal structure of the first dsRBD of TAR RNA-binding protein 2

PDB ID 3llh

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