2v4x

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[[Image:2v4x.png|left|200px]]
 
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{{STRUCTURE_2v4x| PDB=2v4x | SCENE= }}
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==Crystal Structure of Jaagsiekte Sheep Retrovirus Capsid N-terminal domain==
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<StructureSection load='2v4x' size='340' side='right'caption='[[2v4x]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2v4x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Endogenous_jaagziekte_retrovirus Endogenous jaagziekte retrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V4X FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4x OCA], [https://pdbe.org/2v4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v4x RCSB], [https://www.ebi.ac.uk/pdbsum/2v4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4x ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v4x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v4x ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Jaagsiekte sheep retrovirus is a betaretrovirus and the causative agent of pulmonary adenocarcinoma, a transmissible lung tumour of sheep. Here we report the crystal structure of the capsid amino-terminal domain and examine the self-association properties of Jaagsiekte sheep retrovirus capsid. We find that the structure is remarkably similar to the amino-terminal domain of the alpharetrovirus, avian leukosis virus, revealing a previously undetected evolutionary similarity. Examination of capsid self-association suggests a mode of assembly not driven by the strong capsid carboxy-terminal domain interactions that characterise capsid assembly in the lentiviruses. Based on these data, we propose this structure provides a model for the capsid of betaretroviruses including the HML-2 family of endogenous human betaretroviruses.
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===CRYSTAL STRUCTURE OF JAAGSIEKTE SHEEP RETROVIRUS CAPSID N-TERMINAL DOMAIN===
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Structure of the Capsid Amino-Terminal Domain from the Betaretrovirus, Jaagsiekte Sheep Retrovirus.,Mortuza GB, Goldstone DC, Pashley C, Haire LF, Palmarini M, Taylor WR, Stoye JP, Taylor IA J Mol Biol. 2008 Nov 5. PMID:19007792<ref>PMID:19007792</ref>
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{{ABSTRACT_PUBMED_19007792}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2v4x" style="background-color:#fffaf0;"></div>
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[[2v4x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Jaagsiekte_sheep_retrovirus Jaagsiekte sheep retrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4X OCA].
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==See Also==
==See Also==
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*[[Virus coat protein|Virus coat protein]]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019007792</ref><references group="xtra"/>
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__TOC__
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[[Category: Jaagsiekte sheep retrovirus]]
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</StructureSection>
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[[Category: Goldstone, D C.]]
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[[Category: Endogenous jaagziekte retrovirus]]
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[[Category: Haire, L F.]]
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[[Category: Large Structures]]
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[[Category: Mortuza, G B.]]
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[[Category: Goldstone, D C]]
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[[Category: Palmarini, M.]]
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[[Category: Haire, L F]]
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[[Category: Pashley, C.]]
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[[Category: Mortuza, G B]]
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[[Category: Stoye, J P.]]
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[[Category: Palmarini, M]]
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[[Category: Taylor, I A.]]
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[[Category: Pashley, C]]
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[[Category: Taylor, W R.]]
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[[Category: Stoye, J P]]
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[[Category: Taylor, I A]]
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[[Category: Taylor, W R]]
[[Category: Capsid]]
[[Category: Capsid]]
[[Category: Capsid protein]]
[[Category: Capsid protein]]

Current revision

Crystal Structure of Jaagsiekte Sheep Retrovirus Capsid N-terminal domain

PDB ID 2v4x

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