2na2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:25, 15 March 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==DROSHA QUAD MUTANT DOUBLE-STRANDED RNA BINDING COMPETENT==
==DROSHA QUAD MUTANT DOUBLE-STRANDED RNA BINDING COMPETENT==
-
<StructureSection load='2na2' size='340' side='right' caption='[[2na2]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+
<StructureSection load='2na2' size='340' side='right'caption='[[2na2]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2na2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NA2 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2na2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NA2 FirstGlance]. <br>
-
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2na2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2na2 OCA], [https://pdbe.org/2na2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2na2 RCSB], [https://www.ebi.ac.uk/pdbsum/2na2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2na2 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2na2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2na2 OCA], [http://pdbe.org/2na2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2na2 RCSB], [http://www.ebi.ac.uk/pdbsum/2na2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2na2 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/RNC_HUMAN RNC_HUMAN]] Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.<ref>PMID:10948199</ref> <ref>PMID:14508493</ref> <ref>PMID:15589161</ref> <ref>PMID:15574589</ref> <ref>PMID:15531877</ref> <ref>PMID:15565168</ref> <ref>PMID:16751099</ref> <ref>PMID:16906129</ref> <ref>PMID:17159994</ref>
+
[https://www.uniprot.org/uniprot/RNC_HUMAN RNC_HUMAN] Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.<ref>PMID:10948199</ref> <ref>PMID:14508493</ref> <ref>PMID:15589161</ref> <ref>PMID:15574589</ref> <ref>PMID:15531877</ref> <ref>PMID:15565168</ref> <ref>PMID:16751099</ref> <ref>PMID:16906129</ref> <ref>PMID:17159994</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Ribonuclease III]]
+
[[Category: Homo sapiens]]
-
[[Category: Kranick, J C]]
+
[[Category: Large Structures]]
-
[[Category: Sahu, D]]
+
[[Category: Kranick JC]]
-
[[Category: Showalter, S A]]
+
[[Category: Sahu D]]
-
[[Category: Drosha]]
+
[[Category: Showalter SA]]
-
[[Category: Hydrolase]]
+
-
[[Category: Nuclear protein-rna binding protein complex]]
+

Current revision

DROSHA QUAD MUTANT DOUBLE-STRANDED RNA BINDING COMPETENT

PDB ID 2na2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/2na2"
Personal tools