6t6f

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m (Protected "6t6f" [edit=sysop:move=sysop])
Current revision (12:55, 24 January 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6t6f is ON HOLD
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==Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 8 (CS275)==
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<StructureSection load='6t6f' size='340' side='right'caption='[[6t6f]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6t6f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T6F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MMW:2-[(3~{S})-3-azanylpiperidin-1-yl]-4-[[3-(trifluoromethyl)phenyl]amino]pyrimidine-5-carboxamide'>MMW</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t6f OCA], [https://pdbe.org/6t6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t6f RCSB], [https://www.ebi.ac.uk/pdbsum/6t6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t6f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCC1D_HUMAN KCC1D_HUMAN] Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.<ref>PMID:11050006</ref> <ref>PMID:15840691</ref> <ref>PMID:16324104</ref> <ref>PMID:17056143</ref>
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Authors: Sorrell, F., Kraemer, A., Butterworth, S., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]]
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Description: Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 8 (CS275)
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Butterworth, S]]
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__TOC__
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[[Category: Knapp, S]]
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</StructureSection>
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[[Category: Edwards, A.M]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Large Structures]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Sorrell, F]]
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[[Category: Butterworth S]]
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[[Category: Kraemer, A]]
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[[Category: Edwards AM]]
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[[Category: Knapp S]]
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[[Category: Kraemer A]]
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[[Category: Sorrell F]]

Current revision

Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) bound to compound 8 (CS275)

PDB ID 6t6f

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