6jvm

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'''Unreleased structure'''
 
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The entry 6jvm is ON HOLD until Oct 22 2021
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==Crystal structure of human MTH1 in complex with compound MI1016==
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<StructureSection load='6jvm' size='340' side='right'caption='[[6jvm]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6jvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JVM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.098&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CGX:N4-cyclopropyl-5-ethyl-6-piperidin-1-yl-pyrimidine-2,4-diamine'>CGX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jvm OCA], [https://pdbe.org/6jvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jvm RCSB], [https://www.ebi.ac.uk/pdbsum/6jvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jvm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
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Authors: Peng, C., Li, Y.H., Cheng, Y.S.
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==See Also==
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*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]]
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Description: Crystal structure of human MTH1 in complex with compound MI1016
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Cheng, Y.S]]
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__TOC__
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[[Category: Li, Y.H]]
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</StructureSection>
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[[Category: Peng, C]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cheng YS]]
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[[Category: Li YH]]
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[[Category: Peng C]]

Current revision

Crystal structure of human MTH1 in complex with compound MI1016

PDB ID 6jvm

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