1e6e

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[[Image:1e6e.png|left|200px]]
 
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{{STRUCTURE_1e6e| PDB=1e6e | SCENE= }}
{{STRUCTURE_1e6e| PDB=1e6e | SCENE= }}
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===ADRENODOXIN REDUCTASE/ADRENODOXIN COMPLEX OF MITOCHONDRIAL P450 SYSTEMS===
===ADRENODOXIN REDUCTASE/ADRENODOXIN COMPLEX OF MITOCHONDRIAL P450 SYSTEMS===
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{{ABSTRACT_PUBMED_11053423}}
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{{ABSTRACT_PUBMED_11053423}}
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==Function==
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[[http://www.uniprot.org/uniprot/ADRO_BOVIN ADRO_BOVIN]] Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. [[http://www.uniprot.org/uniprot/ADX_BOVIN ADX_BOVIN]] Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to cytochrome P450 cholesterol side-chain cleavage enzyme. reductase to the cholesterol side chain cleavage cytochrome P450 (By similarity).
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:011053423</ref><ref group="xtra">PMID:009188745</ref><references group="xtra"/>
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<ref group="xtra">PMID:011053423</ref><references group="xtra"/><references/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Cytochrome p450]]
[[Category: Cytochrome p450]]

Revision as of 03:08, 20 September 2013

Template:STRUCTURE 1e6e

Contents

ADRENODOXIN REDUCTASE/ADRENODOXIN COMPLEX OF MITOCHONDRIAL P450 SYSTEMS

Template:ABSTRACT PUBMED 11053423

Function

[ADRO_BOVIN] Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. [ADX_BOVIN] Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to cytochrome P450 cholesterol side-chain cleavage enzyme. reductase to the cholesterol side chain cleavage cytochrome P450 (By similarity).

About this Structure

1e6e is a 4 chain structure with sequence from Bos taurus. The October 2006 RCSB PDB Molecule of the Month feature on Cytochrome p450 by David S. Goodsell is 10.2210/rcsb_pdb/mom_2006_10. Full crystallographic information is available from OCA.

See Also

Reference

  • Muller JJ, Lapko A, Bourenkov G, Ruckpaul K, Heinemann U. Adrenodoxin reductase-adrenodoxin complex structure suggests electron transfer path in steroid biosynthesis. J Biol Chem. 2001 Jan 26;276(4):2786-9. Epub 2000 Oct 25. PMID:11053423 doi:http://dx.doi.org/10.1074/jbc.M008501200

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OCA

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