2cag

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[[Image:2cag.gif|left|200px]]<br /><applet load="2cag" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2cag.gif|left|200px]]
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caption="2cag, resolution 2.7&Aring;" />
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'''CATALASE COMPOUND II'''<br />
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{{Structure
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|PDB= 2cag |SIZE=350|CAPTION= <scene name='initialview01'>2cag</scene>, resolution 2.7&Aring;
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|SITE= <scene name='pdbsite=DH:Distal+HIS'>DH</scene> and <scene name='pdbsite=PT:Proximal+TYR'>PT</scene>
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN IX CONTAINING FE'>HEM</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6]
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|GENE=
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}}
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'''CATALASE COMPOUND II'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2CAG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Proteus_mirabilis Proteus mirabilis] with <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 2CAG with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb57_1.html Catalase]]. Active as [http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] Known structural/functional Sites: <scene name='pdbsite=DH:Distal+HIS'>DH</scene> and <scene name='pdbsite=PT:Proximal+TYR'>PT</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CAG OCA].
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2CAG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Proteus_mirabilis Proteus mirabilis]. The following page contains interesting information on the relation of 2CAG with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb57_1.html Catalase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CAG OCA].
==Reference==
==Reference==
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Ferryl intermediates of catalase captured by time-resolved Weissenberg crystallography and UV-VIS spectroscopy., Gouet P, Jouve HM, Williams PA, Andersson I, Andreoletti P, Nussaume L, Hajdu J, Nat Struct Biol. 1996 Nov;3(11):951-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8901874 8901874]
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Ferryl intermediates of catalase captured by time-resolved Weissenberg crystallography and UV-VIS spectroscopy., Gouet P, Jouve HM, Williams PA, Andersson I, Andreoletti P, Nussaume L, Hajdu J, Nat Struct Biol. 1996 Nov;3(11):951-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8901874 8901874]
[[Category: Catalase]]
[[Category: Catalase]]
[[Category: Proteus mirabilis]]
[[Category: Proteus mirabilis]]
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[[Category: peroxidase]]
[[Category: peroxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:46:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:13:00 2008''

Revision as of 14:13, 20 March 2008

Image:2cag.gif


PDB ID 2cag

Drag the structure with the mouse to rotate
, resolution 2.7Å
Sites: and
Ligands:
Activity: Catalase, with EC number 1.11.1.6
Coordinates: save as pdb, mmCIF, xml



CATALASE COMPOUND II


Overview

Various enzymes use semi-stable ferryl intermediates and free radicals during their catalytic cycle, amongst them haem catalases. Structures for two transient intermediates (compounds I and II) of the NADPH-dependent catalase from Proteus mirabilis (PMC) have been determined by time-resolved X-ray crystallography and single crystal microspectrophotometry. The results show the formation and transformation of the ferryl group in the haem, and the unexpected binding of an anion during this reaction at a site distant from the haem.

About this Structure

2CAG is a Single protein structure of sequence from Proteus mirabilis. The following page contains interesting information on the relation of 2CAG with [Catalase]. Full crystallographic information is available from OCA.

Reference

Ferryl intermediates of catalase captured by time-resolved Weissenberg crystallography and UV-VIS spectroscopy., Gouet P, Jouve HM, Williams PA, Andersson I, Andreoletti P, Nussaume L, Hajdu J, Nat Struct Biol. 1996 Nov;3(11):951-6. PMID:8901874

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