1ofc
From Proteopedia
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1OFC is a | + | 1OFC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with GLC, G4D and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OFC OCA]. |
==Reference== | ==Reference== | ||
| Line 25: | Line 25: | ||
[[Category: sant domain]] | [[Category: sant domain]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:18:02 2007'' |
Revision as of 12:12, 5 November 2007
|
NUCLEOSOME RECOGNITION MODULE OF ISWI ATPASE
Overview
Energy-dependent nucleosome remodeling emerges as a key process endowing, chromatin with dynamic properties. However, the principles by which, remodeling ATPases interact with their nucleosome substrate to alter, histone-DNA interactions are only poorly understood. We have identified a, substrate recognition domain in the C-terminal half of the remodeling, ATPase ISWI and determined its structure by X-ray crystallography. The, structure comprises three domains, a four-helix domain with a novel fold, and two alpha-helical domains related to the modules of c-Myb, SANT and, SLIDE, which are linked by a long helix. An integrated structural and, functional analysis of these domains provides insight into how ISWI, interacts with the nucleosomal substrate.
About this Structure
1OFC is a Single protein structure of sequence from Drosophila melanogaster with GLC, G4D and GOL as ligands. Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI., Grune T, Brzeski J, Eberharter A, Clapier CR, Corona DF, Becker PB, Muller CW, Mol Cell. 2003 Aug;12(2):449-60. PMID:14536084
Page seeded by OCA on Mon Nov 5 14:18:02 2007
