CHEM2052 Tutorial Example4
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==CHEM2052_Tutorial_Example4== | ==CHEM2052_Tutorial_Example4== | ||
| - | <scene name=' | + | <scene name='55/559112/Renin_catalytic_residues/1'>Renin Catalytic Residues</scene> |
Revision as of 06:14, 12 August 2014
Contents |
CHEM2052_Tutorial_Example4
Background
In later lecture we will look at an enzyme called Renin (also known as angiotensinase). This enzyme is involved in a biological pathway leading to elevation of blood pressure, which can be beneficial in many ways. However if this process has become overactive, hypertension (high blood pressure) can result. Hypertension leads to cardiovascular disease which is the leading cause of death globally. The World Health Organisation states "An estimated 17.3 million people died from cardiovascular disease in 2008, representing 30% of all global deaths" see the following web page if you want to know more: [1].
Since the 1970s Renin Wikipedia Site scientists have been trying to modulate the action of renin by blocking the active site of the enzyme and preventing its function, hence lowering blood pressure. Aliskerin is the only renin inhibitor in clinical use today. However there is still interest in developing new, improved inhibitors. This question looks at a renin inhibitor identified through research at Pfizer.
Active Site and Mechanism
Inhibitors
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
