Rab5 GDP/GTP exchange factor
From Proteopedia
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== Function == | == Function == | ||
| - | '''Rab5 GDP/GTP exchange factor''' (Rabex5) is a guanine nucleotide exchange factor. Rabex5 stimulates nucleotide exchange on Rab5. Rabex can act as a ubiqiutin ligase. It forms a tight complex with rabaptin which augments its exchange activity. The rabex5-rabaptin complex is critical to endosomal fusion. | + | '''Rab5 GDP/GTP exchange factor''' (Rabex5) is a guanine nucleotide exchange factor. Rabex5 stimulates nucleotide exchange on Rab5. Rabex can act as a ubiqiutin ligase. It forms a tight complex with rabaptin which augments its exchange activity. The rabex5-rabaptin complex is critical to endosomal fusion<ref>PMID:9323142</ref>. |
== Disease == | == Disease == | ||
Revision as of 06:53, 3 August 2016
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3D Structures of Rab5 GDP/GTP exchange factor
Updated on 03-August-2016
1txu – hRabex5 Vps9 domain – human
4n3x – hRabex5 CC domain
2fid, 2fif – bRabex5 zinc finger and ubiquitin interacting motif + ubiquitin – bovine
2c7m, 2c7n – hRabex5 ubiquitin interacting motif + ubiquitin
2ot3 – hRabex5 Vps9 domain + Ras-related protein Rab21
4n3x – hRabex5 CC domain + Rabaptin
4n3z – hRabex5 5δ + Rabaptin
4q9u – hRabex5 5δ (mutant) + Ras-related protein Rab5A
4n3y – hRabex5 5CC domain + Rab GTPase-binding effector protein
References
- ↑ Horiuchi H, Lippe R, McBride HM, Rubino M, Woodman P, Stenmark H, Rybin V, Wilm M, Ashman K, Mann M, Zerial M. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell. 1997 Sep 19;90(6):1149-59. PMID:9323142
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