2n9c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 2n9c is ON HOLD until Paper Publication
+
==NRAS Isoform 5==
 +
<StructureSection load='2n9c' size='340' side='right' caption='[[2n9c]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2n9c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N9C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N9C FirstGlance]. <br>
 +
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n9c OCA], [http://pdbe.org/2n9c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n9c RCSB], [http://www.ebi.ac.uk/pdbsum/2n9c PDBsum]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[[http://www.uniprot.org/uniprot/RASN_HUMAN RASN_HUMAN]] Defects in NRAS are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[http://omim.org/entry/607785 607785]]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Defects in NRAS are the cause of Noonan syndrome type 6 (NS6) [MIM:[http://omim.org/entry/613224 613224]]. A syndrome characterized by facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears. Other features can include short stature, a short neck with webbing or redundancy of skin, cardiac anomalies, deafness, motor delay and variable intellectual deficits.<ref>PMID:19966803</ref> Defects in NRAS are the cause of autoimmune lymphoproliferative syndrome type 4 (ALPS4) [MIM:[http://omim.org/entry/614470 614470]]. A disorder of apoptosis, characterized by chronic accumulation of non-malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the development of hematologic malignancies.<ref>PMID:17517660</ref>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/RASN_HUMAN RASN_HUMAN]] Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
It was recently discovered that the NRAS isoform 5 (20 amino acids) is expressed in melanoma and results in a more aggressive cell phenotype. This novel isoform is responsible for increased phosphorylation of downstream targets such as AKT, MEK, and ERK as well as increased cellular proliferation. This structure report describes the NMR solution structure of NRAS isoform 5 to be used as a starting point to understand its biophysical interactions. The isoform is highly flexible in aqueous solution, but forms a helix-turn-coil structure in the presence of trifluoroethanol as determined by NMR and CD spectroscopy.
-
Authors: Markowitz, J., Mal, T.K., Yuan, C., Courtney, N.B., Patel, M., Stiff, A.R., Blachly, J., Walker, C., Eisfeld, A., de la Chapelle, A., Carson III, W.E.
+
Structural characterization of NRAS isoform 5.,Markowitz J, Mal TK, Yuan C, Courtney NB, Patel M, Stiff AR, Blachly J, Walker C, Eisfeld AK, de la Chapelle A, Carson WE 3rd Protein Sci. 2016 May;25(5):1069-74. doi: 10.1002/pro.2916. Epub 2016 Mar 24. PMID:26947772<ref>PMID:26947772</ref>
-
Description: NRAS Isoform 5
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[Category: Unreleased Structures]]
+
</div>
-
[[Category: Yuan, C]]
+
<div class="pdbe-citations 2n9c" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Blachly, J]]
[[Category: Blachly, J]]
-
[[Category: Patel, M]]
+
[[Category: Chapelle, A de la]]
-
[[Category: Carson Iii, W.E]]
+
[[Category: Courtney, N B]]
-
[[Category: Mal, T.K]]
+
-
[[Category: Markowitz, J]]
+
[[Category: Eisfeld, A]]
[[Category: Eisfeld, A]]
 +
[[Category: III, W E.Carson]]
 +
[[Category: Mal, T K]]
 +
[[Category: Markowitz, J]]
 +
[[Category: Patel, M]]
 +
[[Category: Stiff, A R]]
[[Category: Walker, C]]
[[Category: Walker, C]]
-
[[Category: Stiff, A.R]]
+
[[Category: Yuan, C]]
-
[[Category: De La Chapelle, A]]
+
[[Category: Nra]]
-
[[Category: Courtney, N.B]]
+
[[Category: Signaling protein]]

Revision as of 04:40, 11 May 2016

NRAS Isoform 5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/2n9c"
Personal tools