1ofc
From Proteopedia
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| - | [[Image:1ofc.gif|left|200px]]<br /> | + | [[Image:1ofc.gif|left|200px]]<br /><applet load="1ofc" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ofc" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1ofc, resolution 1.90Å" /> | caption="1ofc, resolution 1.90Å" /> | ||
'''NUCLEOSOME RECOGNITION MODULE OF ISWI ATPASE'''<br /> | '''NUCLEOSOME RECOGNITION MODULE OF ISWI ATPASE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1OFC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with GLC, G4D and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 1OFC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with GLC, G4D and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Gol Binding Site For Chain X'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OFC OCA]. |
==Reference== | ==Reference== | ||
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[[Category: sant domain]] | [[Category: sant domain]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 17:40:10 2007'' |
Revision as of 15:30, 18 December 2007
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NUCLEOSOME RECOGNITION MODULE OF ISWI ATPASE
Overview
Energy-dependent nucleosome remodeling emerges as a key process endowing, chromatin with dynamic properties. However, the principles by which, remodeling ATPases interact with their nucleosome substrate to alter, histone-DNA interactions are only poorly understood. We have identified a, substrate recognition domain in the C-terminal half of the remodeling, ATPase ISWI and determined its structure by X-ray crystallography. The, structure comprises three domains, a four-helix domain with a novel fold, and two alpha-helical domains related to the modules of c-Myb, SANT and, SLIDE, which are linked by a long helix. An integrated structural and, functional analysis of these domains provides insight into how ISWI, interacts with the nucleosomal substrate.
About this Structure
1OFC is a Single protein structure of sequence from Drosophila melanogaster with GLC, G4D and GOL as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI., Grune T, Brzeski J, Eberharter A, Clapier CR, Corona DF, Becker PB, Muller CW, Mol Cell. 2003 Aug;12(2):449-60. PMID:14536084
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