176d

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{{Seed}}
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[[Image:176d.png|left|200px]]
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{{STRUCTURE_176d| PDB=176d | SCENE= }}
{{STRUCTURE_176d| PDB=176d | SCENE= }}
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'''NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA'''
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===NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA===
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==Overview==
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Peptide nucleic acids (PNA) incorporating nucleic acid bases into an achiral polyamide backbone bind to DNA in a sequence-dependent manner. The structure of a PNA-ribonucleic acid (RNA) complex was determined with nuclear magnetic resonance methods. A hexameric PNA formed a 1:1 complex with a complementary RNA that is an antiparallel, right-handed double helix with Watson-Crick base pairing similar to the "A" form structure of RNA duplexes. The achiral PNA backbone assumed a distinct conformation upon binding that differed from previously proposed models and provides a basis for further structure-based design of antisense agents.
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The line below this paragraph, {{ABSTRACT_PUBMED_7519361}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7519361 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7519361}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=176D OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=176D OCA].
==Reference==
==Reference==
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[[Category: Pna]]
[[Category: Pna]]
[[Category: Rna]]
[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:33:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:36:04 2008''

Revision as of 12:36, 30 June 2008

Image:176d.png

Template:STRUCTURE 176d

NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA

Template:ABSTRACT PUBMED 7519361

About this Structure

Full experimental information is available from OCA.

Reference

NMR solution structure of a peptide nucleic acid complexed with RNA., Brown SC, Thomson SA, Veal JM, Davis DG, Science. 1994 Aug 5;265(5173):777-80. PMID:7519361

Page seeded by OCA on Mon Jun 30 15:36:04 2008

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