1bb7

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{{STRUCTURE_1bb7| PDB=1bb7 | SCENE= }}
{{STRUCTURE_1bb7| PDB=1bb7 | SCENE= }}
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'''LYSOZYME COMPLEX WITH 4-METHYL-UMBELLIFERYL CHITOBIOSE'''
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===LYSOZYME COMPLEX WITH 4-METHYL-UMBELLIFERYL CHITOBIOSE===
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==Overview==
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Two complexes between rainbow trout lysozyme (RBTL) and 4-methylumbelliferyl chitobioside, 4MeU-(GlcNAc)2, and chitotrioside, 4MeU-(GlcNAc)3, were produced by co-crystallization and soaking, respectively, and the crystal structures were solved at 2.0 A resolution. The results show that 4-MeU-(GlcNAc)3 binds in subsites A-D and that 4-MeU-(GlcNAc)2 binds in subsites B-D in the active-site cleft of RBTL. This agrees well with earlier crystallographic studies on the binding of oligosaccharides of chitin to RBTL, which showed that (GlcNAc)3 binds to sites B-D in RBTL and not to A-C as seen in the human and turkey egg-white lysozymes. For both complexes the 4-MeU moiety in site D has diffuse electron density and is flexible, as it is only bound to water molecules and not to the protein. Since no electron density was observed in site E, the solved structures give views of nonproductive enzyme-substrate complexes.
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{{ABSTRACT_PUBMED_10089395}}
==About this Structure==
==About this Structure==
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[[Category: N-acetyl-muramidase]]
[[Category: N-acetyl-muramidase]]
[[Category: Umbelliferone glycoside]]
[[Category: Umbelliferone glycoside]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:17:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:45:00 2008''

Revision as of 15:45, 30 June 2008

Image:1bb7.png

Template:STRUCTURE 1bb7

LYSOZYME COMPLEX WITH 4-METHYL-UMBELLIFERYL CHITOBIOSE

Template:ABSTRACT PUBMED 10089395

About this Structure

1BB7 is a Single protein structure of sequence from Oncorhynchus mykiss. Full crystallographic information is available from OCA.

Reference

Structural studies on the binding of 4-methylumbelliferone glycosides of chitin to rainbow trout lysozyme., Vollan VB, Hough E, Karlsen S, Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):60-6. Epub 1999 Jan, 1. PMID:10089395

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