6e8h

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Current revision (14:39, 13 March 2024) (edit) (undo)
 
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<StructureSection load='6e8h' size='340' side='right'caption='[[6e8h]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
<StructureSection load='6e8h' size='340' side='right'caption='[[6e8h]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6e8h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E8H OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6E8H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6e8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_longbeachae_NSW150 Legionella longbeachae NSW150]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E8H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6e8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e8h OCA], [http://pdbe.org/6e8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e8h RCSB], [http://www.ebi.ac.uk/pdbsum/6e8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e8h ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e8h OCA], [https://pdbe.org/6e8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e8h RCSB], [https://www.ebi.ac.uk/pdbsum/6e8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e8h ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/D3HJY4_LEGLN D3HJY4_LEGLN]
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Src homology 2 (SH2) domains play a critical role in signal transduction in mammalian cells by binding to phosphorylated Tyr (pTyr). Apart from a few isolated cases in viruses, no functional SH2 domain has been identified to date in prokaryotes. Here we identify 93 SH2 domains from Legionella that are distinct in sequence and specificity from mammalian SH2 domains. The bacterial SH2 domains are not only capable of binding proteins or peptides in a Tyr phosphorylation-dependent manner, some bind pTyr itself with micromolar affinities, a property not observed for mammalian SH2 domains. The Legionella SH2 domains feature the SH2 fold and a pTyr-binding pocket, but lack a specificity pocket found in a typical mammalian SH2 domain for recognition of sequences flanking the pTyr residue. Our work expands the boundary of phosphotyrosine signalling to prokaryotes, suggesting that some bacterial effector proteins have acquired pTyr-superbinding characteristics to facilitate bacterium-host interactions.
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Identification and characterization of a large family of superbinding bacterial SH2 domains.,Kaneko T, Stogios PJ, Ruan X, Voss C, Evdokimova E, Skarina T, Chung A, Liu X, Li L, Savchenko A, Ensminger AW, Li SS Nat Commun. 2018 Oct 31;9(1):4549. doi: 10.1038/s41467-018-06943-2. PMID:30382091<ref>PMID:30382091</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6e8h" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kaneko, T]]
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[[Category: Legionella longbeachae NSW150]]
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[[Category: Li, S S.C]]
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[[Category: Kaneko T]]
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[[Category: Peptide binding protein]]
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[[Category: Li SSC]]
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[[Category: Src homology 2 domain]]
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Current revision

Legionella Longbeachae LeSH (Llo2327)

PDB ID 6e8h

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