1l1v

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[[Image:1l1v.gif|left|200px]]
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{{Seed}}
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[[Image:1l1v.png|left|200px]]
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{{STRUCTURE_1l1v| PDB=1l1v | SCENE= }}
{{STRUCTURE_1l1v| PDB=1l1v | SCENE= }}
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'''UNUSUAL ACTD/DNA_TA COMPLEX STRUCTURE'''
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===UNUSUAL ACTD/DNA_TA COMPLEX STRUCTURE===
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==Overview==
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Many anticancer drugs interact directly with DNA to exert their biological functions. To date, all noncovalent, intercalating drugs interact with DNA exclusively by inserting their chromophores into base steps to form elongated and unwound duplex structures without disrupting the flanking base pairs. By using actinomycin D (ActD)-5'-GXC/CYG-5' complexes as examples, we have found a rather unusual interaction mode for the intercalated drug; the central Watson-Crick X/Y base pairs are looped out and displaced by the ActD chromophore. The looped-out bases are not disordered but interact perpendicularly with the base/chromophore and form specific H bonds with DNA. Such a complex structure provides intriguing insights into how ligand interacts with DNA and enlarges the repertoires for sequence-specific DNA recognition.
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The line below this paragraph, {{ABSTRACT_PUBMED_12011426}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12011426 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12011426}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1V OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1V OCA].
==Reference==
==Reference==
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[[Category: Looped-out]]
[[Category: Looped-out]]
[[Category: Perpendicular]]
[[Category: Perpendicular]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:26:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:31:03 2008''

Revision as of 08:31, 2 July 2008

Image:1l1v.png

Template:STRUCTURE 1l1v

UNUSUAL ACTD/DNA_TA COMPLEX STRUCTURE

Template:ABSTRACT PUBMED 12011426

About this Structure

Full experimental information is available from OCA.

Reference

Looped out and perpendicular: deformation of Watson-Crick base pair associated with actinomycin D binding., Chou SH, Chin KH, Chen FM, Proc Natl Acad Sci U S A. 2002 May 14;99(10):6625-30. PMID:12011426

Page seeded by OCA on Wed Jul 2 11:31:03 2008

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