1odf

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[[Image:1odf.gif|left|200px]]
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{{STRUCTURE_1odf| PDB=1odf | SCENE= }}
{{STRUCTURE_1odf| PDB=1odf | SCENE= }}
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'''STRUCTURE OF YGR205W PROTEIN.'''
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===STRUCTURE OF YGR205W PROTEIN.===
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==Overview==
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The protein product of the YGR205w gene of Saccharomyces cerevisiae was targeted as part of our yeast structural genomics project. YGR205w codes for a small (290 amino acids) protein with unknown structure and function. The only recognizable sequence feature is the presence of a Walker A motif (P loop) indicating a possible nucleotide binding/converting function. We determined the three-dimensional crystal structure of Se-methionine substituted protein using multiple anomalous diffraction. The structure revealed a well known mononucleotide fold and strong resemblance to the structure of small metabolite phosphorylating enzymes such as pantothenate and phosphoribulo kinase. Biochemical experiments show that YGR205w binds specifically ATP and, less tightly, ADP. The structure also revealed the presence of two bound sulphate ions, occupying opposite niches in a canyon that corresponds to the active site of the protein. One sulphate is bound to the P-loop in a position that corresponds to the position of beta-phosphate in mononucleotide protein ATP complex, suggesting the protein is indeed a kinase. The nature of the phosphate accepting substrate remains to be determined.
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(as it appears on PubMed at http://www.pubmed.gov), where 14997573 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14997573}}
==About this Structure==
==About this Structure==
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[[Category: Atp binding protein]]
[[Category: Atp binding protein]]
[[Category: Yeast protein]]
[[Category: Yeast protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:42:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:42:14 2008''

Revision as of 18:42, 27 July 2008

Image:1odf.png

Template:STRUCTURE 1odf

STRUCTURE OF YGR205W PROTEIN.

Template:ABSTRACT PUBMED 14997573

About this Structure

1ODF is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of the YGR205w protein from Saccharomyces cerevisiae: close structural resemblance to E. coli pantothenate kinase., de La Sierra-Gallay IL, Collinet B, Graille M, Quevillon-Cheruel S, Liger D, Minard P, Blondeau K, Henckes G, Aufrere R, Leulliot N, Zhou CZ, Sorel I, Ferrer JL, Poupon A, Janin J, van Tilbeurgh H, Proteins. 2004 Mar 1;54(4):776-83. PMID:14997573

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