1ihm

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[[Image:1ihm.gif|left|200px]]<br /><applet load="1ihm" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ihm.gif|left|200px]]
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caption="1ihm, resolution 3.4&Aring;" />
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'''CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID'''<br />
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{{Structure
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|PDB= 1ihm |SIZE=350|CAPTION= <scene name='initialview01'>1ihm</scene>, resolution 3.4&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1IHM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHM OCA].
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1IHM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHM OCA].
==Reference==
==Reference==
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X-ray crystallographic structure of the Norwalk virus capsid., Prasad BV, Hardy ME, Dokland T, Bella J, Rossmann MG, Estes MK, Science. 1999 Oct 8;286(5438):287-90. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10514371 10514371]
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X-ray crystallographic structure of the Norwalk virus capsid., Prasad BV, Hardy ME, Dokland T, Bella J, Rossmann MG, Estes MK, Science. 1999 Oct 8;286(5438):287-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10514371 10514371]
[[Category: Norwalk virus]]
[[Category: Norwalk virus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: t=3 icosahedral capsid]]
[[Category: t=3 icosahedral capsid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:11:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:50:27 2008''

Revision as of 09:50, 20 March 2008

Image:1ihm.gif


PDB ID 1ihm

Drag the structure with the mouse to rotate
, resolution 3.4Å
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID


Overview

Norwalk virus, a noncultivatable human calicivirus, is the major cause of epidemic gastroenteritis in humans. The first x-ray structure of a calicivirus capsid, which consists of 180 copies of a single protein, has been determined by phase extension from a low-resolution electron microscopy structure. The capsid protein has a protruding (P) domain connected by a flexible hinge to a shell (S) domain that has a classical eight-stranded beta-sandwich motif. The structure of the P domain is unlike that of any other viral protein with a subdomain exhibiting a fold similar to that of the second domain in the eukaryotic translation elongation factor-Tu. This subdomain, located at the exterior of the capsid, has the largest sequence variation among Norwalk-like human caliciviruses and is likely to contain the determinants of strain specificity and cell binding.

About this Structure

1IHM is a Single protein structure of sequence from Norwalk virus. Full crystallographic information is available from OCA.

Reference

X-ray crystallographic structure of the Norwalk virus capsid., Prasad BV, Hardy ME, Dokland T, Bella J, Rossmann MG, Estes MK, Science. 1999 Oct 8;286(5438):287-90. PMID:10514371

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