1lcs
From Proteopedia
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| - | [[Image:1lcs.gif|left|200px]] | + | [[Image:1lcs.gif|left|200px]] |
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| - | '''RECEPTOR-BINDING DOMAIN FROM SUBGROUP B FELINE LEUKEMIA VIRUS''' | + | {{Structure |
| + | |PDB= 1lcs |SIZE=350|CAPTION= <scene name='initialview01'>1lcs</scene>, resolution 2.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=TOE:2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL'>TOE</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= ENV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses]) | ||
| + | }} | ||
| + | |||
| + | '''RECEPTOR-BINDING DOMAIN FROM SUBGROUP B FELINE LEUKEMIA VIRUS''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LCS is a [ | + | 1LCS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LCS OCA]. |
==Reference== | ==Reference== | ||
| - | Structure and mechanism of a coreceptor for infection by a pathogenic feline retrovirus., Barnett AL, Wensel DL, Li W, Fass D, Cunningham JM, J Virol. 2003 Feb;77(4):2717-29. PMID:[http:// | + | Structure and mechanism of a coreceptor for infection by a pathogenic feline retrovirus., Barnett AL, Wensel DL, Li W, Fass D, Cunningham JM, J Virol. 2003 Feb;77(4):2717-29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12552012 12552012] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Viruses]] | [[Category: Viruses]] | ||
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[[Category: antiparallel beta-sandwich glycoprotein]] | [[Category: antiparallel beta-sandwich glycoprotein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:29:21 2008'' |
Revision as of 10:29, 20 March 2008
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| , resolution 2.5Å | |||||||
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| Ligands: | |||||||
| Gene: | ENV (Viruses) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
RECEPTOR-BINDING DOMAIN FROM SUBGROUP B FELINE LEUKEMIA VIRUS
Overview
Infection of T lymphocytes by the cytopathic retrovirus feline leukemia virus subgroup T (FeLV-T) requires FeLIX, a cellular coreceptor that is encoded by an endogenous provirus and closely resembles the receptor-binding domain (RBD) of feline leukemia virus subgroup B (FeLV-B). We determined the structure of FeLV-B RBD, which has FeLIX activity, to a 2.5-A resolution by X-ray crystallography. The structure of the receptor-specific subdomain of this glycoprotein differs dramatically from that of Friend murine leukemia virus (Fr-MLV), which binds a different cell surface receptor. Remarkably, we find that Fr-MLV RBD also activates FeLV-T infection of cells expressing the Fr-MLV receptor and that FeLV-B RBD is a competitive inhibitor of infection under these conditions. These studies suggest that FeLV-T infection relies on the following property of mammalian leukemia virus RBDs: the ability to couple interaction with one of a variety of receptors to the activation of a conserved membrane fusion mechanism. A comparison of the FeLV-B and Fr-MLV RBD structures illustrates how receptor-specific regions are linked to conserved elements critical for postbinding events in virus entry.
About this Structure
1LCS is a Single protein structure of sequence from Viruses. Full crystallographic information is available from OCA.
Reference
Structure and mechanism of a coreceptor for infection by a pathogenic feline retrovirus., Barnett AL, Wensel DL, Li W, Fass D, Cunningham JM, J Virol. 2003 Feb;77(4):2717-29. PMID:12552012
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