2jex

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[[Image:2jex.jpg|left|200px]]<br /><applet load="2jex" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2jex.jpg|left|200px]]
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caption="2jex, resolution 2.35&Aring;" />
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'''TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION'''<br />
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{{Structure
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|PDB= 2jex |SIZE=350|CAPTION= <scene name='initialview01'>2jex</scene>, resolution 2.35&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2JEX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEX OCA].
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2JEX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEX OCA].
==Reference==
==Reference==
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Transcription activator structure reveals redox control of a replication initiation reaction., Sanders CM, Sizov D, Seavers PR, Ortiz-Lombardia M, Antson AA, Nucleic Acids Res. 2007;35(10):3504-15. Epub 2007 May 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17478495 17478495]
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Transcription activator structure reveals redox control of a replication initiation reaction., Sanders CM, Sizov D, Seavers PR, Ortiz-Lombardia M, Antson AA, Nucleic Acids Res. 2007;35(10):3504-15. Epub 2007 May 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17478495 17478495]
[[Category: Bovine papillomavirus type 1]]
[[Category: Bovine papillomavirus type 1]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: viral transcription factor]]
[[Category: viral transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:02:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:41:00 2008''

Revision as of 15:41, 20 March 2008

Image:2jex.jpg


PDB ID 2jex

Drag the structure with the mouse to rotate
, resolution 2.35Å
Coordinates: save as pdb, mmCIF, xml



TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION


Overview

Redox changes are one of the factors that influence cell-cycle progression and that control the processes of cellular proliferation, differentiation, senescence and apoptosis. Proteins regulated through redox-sensitive cysteines have been characterized but specific 'sulphydryl switches' in replication proteins remain to be identified. In bovine papillomavirus type-1, DNA replication begins when the viral transcription factor E2 recruits the viral initiator protein E1 to the origin of DNA replication (ori). Here we show that a novel dimerization interface in the E2 transcription activation domain is stabilized by a disulphide bond. Oxidative cross-linking via Cys57 sequesters the interaction surface between E1 and E2, preventing pre-initiation and replication initiation complex formation. Our data demonstrate that as well as a mechanism for regulating DNA binding, redox reactions can control replication by modulating the tertiary structure of critical protein factors using a specific redox sensor.

About this Structure

2JEX is a Single protein structure of sequence from Bovine papillomavirus type 1. Full crystallographic information is available from OCA.

Reference

Transcription activator structure reveals redox control of a replication initiation reaction., Sanders CM, Sizov D, Seavers PR, Ortiz-Lombardia M, Antson AA, Nucleic Acids Res. 2007;35(10):3504-15. Epub 2007 May 3. PMID:17478495

Page seeded by OCA on Thu Mar 20 17:41:00 2008

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