2m7c
From Proteopedia
(Difference between revisions)
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| - | + | ==Circular Permutation of the Trp-cage: Fold Rescue upon Addition of a Hydrophobic Staple== | |
| - | + | <StructureSection load='2m7c' size='340' side='right' caption='[[2m7c]], [[NMR_Ensembles_of_Models | 32 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[2m7c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M7C FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ll5|2ll5]], [[3uc7|3uc7]], [[3uc8|3uc8]], [[2jof|2jof]], [[1l2y|1l2y]], [[2ldj|2ldj]], [[2m7d|2m7d]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m7c RCSB], [http://www.ebi.ac.uk/pdbsum/2m7c PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Trp-cage, at 20 residues in length, is generally acknowledged as the smallest fully protein-like folding motif. Linking the termini by a two-residue unit and excising one residue affords circularly permuted sequences that adopt the same structure. This represents the first successful circular permutation of any fold of less than 50-residue length. As was observed for the original topology, a hydrophobic staple near the chain termini is required for enhanced fold stability. | ||
| - | + | Circular Permutation of the Trp-cage: Fold Rescue upon Addition of a Hydrophobic Staple.,Byrne A, Kier BL, Williams DV, Scian M, Andersen NH RSC Adv. 2013 Nov 21;2013(43). doi: 10.1039/C3RA43674H. PMID:24376912<ref>PMID:24376912</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Andersen, N H | + | == References == |
| - | [[Category: Byrne, A | + | <references/> |
| - | [[Category: Kier, B L | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Andersen, N H]] | ||
| + | [[Category: Byrne, A]] | ||
| + | [[Category: Kier, B L]] | ||
[[Category: Circular permutant]] | [[Category: Circular permutant]] | ||
[[Category: De novo protein]] | [[Category: De novo protein]] | ||
Revision as of 18:09, 19 January 2015
Circular Permutation of the Trp-cage: Fold Rescue upon Addition of a Hydrophobic Staple
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